人重组干扰素-α-2b在子宫内膜异位症治疗中的研究  

A Study on the Human Interferon-α-2b in the Treatment of Endometriosis

作　　者：孙俊杰[1] 孙利娟[1] 马洪达[2] 尹利荣[1] 糜若然[3] 

机构地区：[1]天津医科大学第二医院妇科,300211 [2]天津医科大学病理学教研室 [3]天津医科大学总医院

出　　处：《天津医药》2009年第12期1007-1010,共4页Tianjin Medical Journal

基　　金：天津医科大学第二医院基金资助项目(项目编号:Y0601)

摘　　要：目的:探讨手术联合人重组干扰素-α-2b(IFN-α-2b)治疗子宫内膜异位症(内异症)的效果。方法:45例内异症患者分为3组,试验组(手术+人重组IFN-α-2b联合治疗)15例,对照组A(手术+达菲林联合治疗)20例,对照组B(单纯手术治疗)10例。各组患者分别于术前、术后1、2、3个月,采用微粒子酶免疫化学发光法检测血清CA125水平和用ELISA方法检测血清子宫内膜抗体(EMAb)水平。术后随访,评估临床情况,并记录联合应用人重组IFN-α-2b治疗的不良反应。结果:(1)试验组和对照组A于术后1～3个月血清CA125和EMAb水平均较术前明显降低(均P<0.05);试验组和对照组A间术前、术后1、2、3个月血清CA125和EMAb水平差异无统计学意义(均P>0.05);试验组和对照组B间术前血清CA125和EMAb水平差异无统计学意义(均P>0.05),而术后1个月时试验组较对照组B的EMAb水平降低(P<0.05)。(2)随访观察联合使用人重组IFN-α-2b治疗后有低热、关节肌肉酸痛及胃肠道不适等不良反应,停药后症状完全消失。结论:手术联合人重组IFN-α-2b治疗内异症的CA125和EMAb的水平与联合达菲林治疗基本相似,均比单纯手术治疗效果好。Objective：To investigate the effect of human interferon-α-2b （IFN-α-2b） in the treatment of endometriosis by detecting the levels of CA125 and endometrial antibody（EMAb）. Methods： Forty-five cases with endometriosis were divid- ed into three groups. Fifteen cases in test group （operation＋IFN-α-2b）, 20 cases in control group A （operation＋Diphereline）, 10 cases in control group B （only operation）. The blood serum level of CA125 was detected by microparticle enzyme immuno- chemiluminescent at pre-operation, the first month, second month and third month of the post-operation; and the EMAb level was measured by enzyme linked immunosorbent assay （ELISA）. The follow-up of patients was carried out after operation to e- valuate the clinical appearances and record the adverse effects of the human IFN-α-2b. Results： Compared with pre-opera- tion, the levels of CA125 and EMAb were obviously degraded in the first to third months after surgery in test group and control group A （P 0.05）. There were no significant difference in the levels of CA125 and EMAb were at pre-operation,the first month,second month and third month of the post-operation between the test group and control group A（P 0.05）. There were no significant difference in the levels of CA125 and EMAb at pre-operation between the test group and control group B （P 0.05）. However, the level of EMAb was lower the first month after operation in the test group than that of control group B. In the follow-up, the adverse effects of the human interferon-α-2b were observed including low-grade fever, articular muscle sore- ness and gastrointestinal tract complaints. These appearances completely disappeared after drug withdrawal. It had less impact on the menstruation. Conclusion： The levels of CA125 and EMAb were similar in treatment of endometriosis with human IFN- α-2b and with Diphereline. Both of the treatments are better than the pure surgery. It has less impact on the menstruation and can avoid menostasia.

关 键 词：子宫内膜异位症 干扰素Α-2B 促性腺素释放激素 酶联免疫吸附测定 自身抗体 CA-125抗原 

分 类 号：R733.7[医药卫生—肿瘤] R711.71[医药卫生—临床医学]