莪术醇自体瘤苗治疗胃癌的初步研究  被引量:6

Curative effect in gastric cancer patients with autologous tumor cell vaccine curcuma modified

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作  者:徐立春[1] 陈平 卜平[1] 刘晓丹 高鹏 王耀霞[1] 

机构地区:[1]扬州大学中西医结合研究所,江苏扬州225001 [2]扬州大学第一临床医院外科,江苏扬州225001 [3]扬州大学第二临床医院外科,江苏扬州225002 [4]扬州市中医院肿瘤科,江苏扬州225003

出  处:《中华肿瘤防治杂志》2009年第20期1587-1589,共3页Chinese Journal of Cancer Prevention and Treatment

基  金:江苏省医学卫生重大科研课题(K200511);扬州市-扬州大学资助基金(YZ2007-049-9)

摘  要:目的:探讨莪术醇自体瘤苗治疗胃腺癌的初步试验临床效果。方法:用现代生物技术构建莪术醇自体瘤苗,对16例胃实体瘤术后患者进行自体瘤苗免疫接种,并设对照组10例,检测各组治疗前后其NKC活性、CD3+、CD4+和CD8+水平及生存质量的改变,对其疗效进行判断评价。结果:经莪术醇自体瘤苗免疫接种治疗后实验组CD3+、CD4+和CD8+水平及NKC活性分别为49.46±5.84、48.35±4.00、28.92±3.30和11.36±2.64,其NKC细胞的活性、CD3+、CD4+水平与对照组及自身治疗前比较有明显差异;近期随诊其生存质量及疗效也明显优于自身治疗前及对照组。结论:莪术醇自体瘤苗治疗胃腺癌患者,能明显提高机体免疫功能,促进自身生存质量的改善,对胃腺癌有较好的治疗效应。OBJECTIVE:To explore the curative effect on the stomach tumour patients with autologous tumor cell vaccine curcumal modified.METHODS:Sixteen patients with gastric cancer were treated with autologous tumor cell vaccine curcumal modified,and other 10 cases just operated served as a control group.The levels of CD3+,CD4+,CD8+ and activity of NK cells were tested before and after the operation.RESULTS:The levels of CD3+,CD4+,CD8+ and the NKC activity in the experimental group which accepted the autologous tumor cell vaccine immunization were 49.46±5.84,48.35±4.00,28.92 ± 3.30,11.36±2.64,respectively.There was a significant difference of the NKC activity and levels of CD3+ and CD4+ between the pre-treatment and post-treatment with autologous tumor cell vaccine.The quality of life and the effective of treatment was significantly better in the post-treatment than pre-treatment and the control group.CONCLUSION:The therapy of vaccine curcuma modified can restore cellular immunity so as to enhance the efficacy of the treatment,and the clinical symptoms and signs are significantly improved.

关 键 词:免疫疗法 胃肿瘤 免疫功能 治疗效应 

分 类 号:R735.2[医药卫生—肿瘤]

 

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