莪术醇自体瘤苗治疗胃癌的初步研究  

Curative effect in gastric cancer patients with autologous tumor cell vaccine curcuma modified

作　　者：徐立春[1] 陈平 卜平[1] 刘晓丹 高鹏 王耀霞[1] 

机构地区：[1]扬州大学中西医结合研究所,江苏扬州225001 [2]扬州大学第一临床医院外科,江苏扬州225001 [3]扬州大学第二临床医院外科,江苏扬州225002 [4]扬州市中医院肿瘤科,江苏扬州225003

出　　处：《中华肿瘤防治杂志》2009年第20期1587-1589,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：江苏省医学卫生重大科研课题(K200511);扬州市-扬州大学资助基金(YZ2007-049-9)

摘　　要：目的:探讨莪术醇自体瘤苗治疗胃腺癌的初步试验临床效果。方法:用现代生物技术构建莪术醇自体瘤苗,对16例胃实体瘤术后患者进行自体瘤苗免疫接种,并设对照组10例,检测各组治疗前后其NKC活性、CD3+、CD4+和CD8+水平及生存质量的改变,对其疗效进行判断评价。结果:经莪术醇自体瘤苗免疫接种治疗后实验组CD3+、CD4+和CD8+水平及NKC活性分别为49.46±5.84、48.35±4.00、28.92±3.30和11.36±2.64,其NKC细胞的活性、CD3+、CD4+水平与对照组及自身治疗前比较有明显差异;近期随诊其生存质量及疗效也明显优于自身治疗前及对照组。结论:莪术醇自体瘤苗治疗胃腺癌患者,能明显提高机体免疫功能,促进自身生存质量的改善,对胃腺癌有较好的治疗效应。OBJECTIVE：To explore the curative effect on the stomach tumour patients with autologous tumor cell vaccine curcumal modified.METHODS：Sixteen patients with gastric cancer were treated with autologous tumor cell vaccine curcumal modified,and other 10 cases just operated served as a control group.The levels of CD3＋,CD4＋,CD8＋ and activity of NK cells were tested before and after the operation.RESULTS：The levels of CD3＋,CD4＋,CD8＋ and the NKC activity in the experimental group which accepted the autologous tumor cell vaccine immunization were 49.46±5.84,48.35±4.00,28.92 ± 3.30,11.36±2.64,respectively.There was a significant difference of the NKC activity and levels of CD3＋ and CD4＋ between the pre-treatment and post-treatment with autologous tumor cell vaccine.The quality of life and the effective of treatment was significantly better in the post-treatment than pre-treatment and the control group.CONCLUSION：The therapy of vaccine curcuma modified can restore cellular immunity so as to enhance the efficacy of the treatment,and the clinical symptoms and signs are significantly improved.

关 键 词：免疫疗法 胃肿瘤 免疫功能 治疗效应 

分 类 号：R735.2[医药卫生—肿瘤]