多层螺旋CT联合血清淀粉样蛋白A对结肠癌术前分期诊断价值的随机对照研究  

Randomized controll trial of combinative assessment of multi-slice spiral computer tomography and serum amyloid a protein on preoperative staging in colonic cancer

作　　者：汪晓东[1] 吕东昊 张琼文 纳飞飞 吴俊华[3] 李臻辉[4] 李立[1] 

机构地区：[1]四川大学华西医院肛肠外科,四川成都610041 [2]四川大学华西临床医学院肛肠外科,四川成都610041 [3]四川大学华西医院放射科,四川成都610041 [4]四川大学华西医院实验医学科,四川成都610041

出　　处：《中华肿瘤防治杂志》2009年第20期1590-1593,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：四川省卫生厅科研课题(080278)

摘　　要：目的:探讨64排多层螺旋CT(MSCT)联合血清淀粉样蛋白A(SAA)在结肠癌术前分期中的临床应用价值。方法:110例结肠癌患者,随机分为A组(55例)和B组(55例),A组术前行MSCT和SAA联合评估,B组只进行MSCT评估,比较术前分期与术后病理分期。结果:实际纳入病例99例,A组49例,B组50例,2组基线情况一致。A组的术前T、N、M及TNM分期的准确度分别为81.6%、79.6%、100%及77.6%;而B组准确度分别为82.0%、60.0%、98.0%及62.0%。两组在N分期之间的差异有统计学意义,χ2=4.498,P=0.034。结论:MSCT和SAA联合术前分期评估结肠癌患者的策略可以提高术前分期的准确性。OBJECTIVE：To determine the value of combination of 64 multi-slice spiral computer tomography（MSCT）and serum amyloid A protein（SAA）in preoperative staging of colonic cancer.METHODS：A total of 110 patients definitely diagnosed as colonic cancer were randomly assigned into Group A and Group B with 55 participants respectively.In Group A,the combinative assessment were made for preoperative evaluation,while only MSCT was made preoperatively in Group B.Furthermore,the preoperative staging was compared with the postoperative pathological finding.RESULTS：According to the inclusion criteria,99 colonic cancer patients were finally included into Group A（n=49）and Group B（n=50）.The baseline characteristics of the two groups were statistically similar.For Group A,the accuracies of preoperative staging T,N,M and TNM were 81.6%,79.6%,100% and 77.6%,respectively.For Group B,the corresponding rates were 82.0%,60.0%,98.0%,62.0%,respectively.The difference of accuracies on staging N between the two groups was observed statistically（χ2=4.498,P=0.034）.CONCLUSION：The strategy of the combinative assessment of MSCT and SAA can improve the accuracy of preoperative staging in colonic cancer.

关 键 词：结肠肿瘤 体层摄影术/螺旋计算机 血清淀粉样蛋白A 术前分期 

分 类 号：R735.35[医药卫生—肿瘤]