HIF-1α和MMP-9表达与脑胶质瘤血管形成和瘤周水肿的关系  

Relationship between expressions of HIF-1α and MMP-9 and angiogenesis and peritumorous edema of glioma

作　　者：刘谦东[1] 孙国庆[1] 刘爱军 郑莉伟 王恩芹[1] 熊峰[1] 

机构地区：[1]日照市人民医院神经外科,山东日照276826 [2]日照市五莲县人民医院门诊部,山东五莲262301 [3]日照市妇幼保健院妇产科,山东日照276826

出　　处：《中华肿瘤防治杂志》2009年第21期1654-1656,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨缺氧诱导因子-1α(HIF-1α)和基质金属蛋白酶-9(MMP-9)表达与脑胶质瘤血管形成、瘤周血管源性脑水肿的关系。方法:免疫组化法检测胶质瘤和对照组标本中HIF-1α、MMP-9和CD34的表达,MRI判断瘤周水肿的程度。结果:HIF-1α阴性组微血管密度为(18.45±4.23)个/视野,HIF-1α阳性组为(45.23±18.56)个/视野,两者间差异有统计学意义,P<0.05;MMP-9阴性组微血管密度为(12.40±2.62)个/视野,MMP-9阳性组为(36.40±22.21)个/视野,两者间差异有统计学意义,P<0.05;HIF-1α阳性组与阴性组水肿指数比较,前者明显大于后者,P<0.05;MMP-9阳性组与阴性组水肿指数比较,前者明显大于后者,P<0.05;胶质瘤HIF-1α、MMP-9的半定量计分与瘤周水肿体积作等级相关分析,呈显著性正相关关系。结论:HIF-1α、MMP-9参与了胶质瘤的血管形成,并可增加血管的通透性,与肿瘤的生长、侵袭密切相关,HIF-1α、MMP-9与微血管密度及水肿指数的结合有利于临床对胶质瘤转归及预后的预测。OBJECTIVE：To investigate the relationship between expressions HIF-1α and MMP-9,angiogenesis and peritumorous brain edema of gliomas.METHODS：The expressions of HIF-1α,MMP-9 and CD-34-related antigen were evaluated by immunohistochemical technique in the samples of 40 gliomas and 10 control tissues,MRI was used for the content of peritumorous edema.RESULTS：Emicrovascular density（MVD）was 18.45±4.23 per vision in HIF-1αnegative group and 45.23±18.56 in HIF-1αpositive group.there was a difference between them（P〈0.05）;Emicrovascular density（MVD）was 12.40±2.62 per vision in MMP-9 negative group and 36.40±22.21 in MMP-9 positive group.there was a difference between them（P〈0.05）;The edema index（EI）was larger in HIF-1α positive cases than in negative ones（P〈0.05）;The edema index（EI）was larger in MMP-9 positive cases than in negative ones（P〈0.05）;The semi-quantitative scale of HIF-1α,MMP-9 was correlated with the volume of peritumorous edema.CONCLUSIONS：HIF-1α,MMP-9 produced by gliomas contributes to the angiogenesis and the increased permeability of microvessel,which closely corelates with the growth and development of gliomas.HIF-1α,MMP-9 combined with MVD and EI is helpful in judging the prognosis,and makes a new way of treatment to gliomas.

关 键 词：神经胶质瘤 基质金属蛋白酶类 脑水肿/病理学 新生血管化 病理性 

分 类 号：R739.4[医药卫生—肿瘤]