肿瘤干细胞与干细胞:来源、分化及其相关性  

Cancer stem cells and stem cells:Source,differentiation and their correlation

作　　者：凌斌[1] 陈静[1] 孙洁[1] 

机构地区：[1]云南省第二人民医院ICU科,云南省昆明市650021

出　　处：《中国组织工程研究与临床康复》2009年第49期9743-9746,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：云南省自然科学基金(2007C249M)~~

摘　　要：肿瘤干细胞是随着干细胞研究的逐步深入脱颖而出的一个新领域,虽其历史不长,但发展势头迅猛,呈现出潜在的良好前景。肿瘤干细胞的存在及其作为肿瘤形成、生长和转移基础的观点已得到广泛认同。在理论上,肿瘤干细胞既可来源于正常干细胞的转化,也可来源于致癌因素诱导下的去分化细胞,由于其包含全能、多能和单能干细胞,具备增殖和向不同方向分化的潜能,可据以解释肿瘤细胞的异质性以及对缺氧环境、抗癌药和放射线适应能力的原因。近些年来在该领域已取得了许多进展,但仍存在一些亟待解决的问题,如肿瘤干细胞的鉴定、生物学功能及作用机制等。Cancer stem cells are a new field with the gradual deep understanding of the stem cell research.Although its history is not long,the rapid development showed a good potential prospect.The existence of cancer stem cells and its use as tumor formation,growth and metastasis-based approach has been widely recognized.In theory,cancer stem cells derived from normal stem cells can transform.Cancer-causing factors can also be derived from the dedifferentiation induced cells.Because it contains all-round,multi-and single stem cell,with the proliferation and differentiation potential of different directions,it is possible to explain the heterogeneity of tumor cells,and reasons for hypoxic environment,anti-cancer drugs and radiation resilience.In this area,it has been made a lot of progress in recent years.However,there are still some problems to be solved.Such as the identification of cancer stem cells,biological function and mechanism.

关 键 词：干细胞 肿瘤干细胞 肿瘤 筛选 

分 类 号：R394.2[医药卫生—医学遗传学]