NKG2D及其配体在消化系肿瘤中的研究进展  

Advances in understanding the role of NKG2D and its ligands in digestive system tumors

作　　者：万娟[1] 李国华[1] 

机构地区：[1]南昌大学第一附属医院消化科,江西省南昌市330006

出　　处：《世界华人消化杂志》2009年第31期3233-3236,共4页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.30760086~~

摘　　要：NKG2D为NK细胞表面的C型凝集素样活化性受体,其配体主要表达于炎性细胞和肿瘤细胞表面,在正常细胞表面很少表达甚至不表达.近来实验证实肿瘤细胞中,NKG2D表达下调,而其可溶性配体的表达明显增加,NKG2D介导的抗肿瘤反应在天然免疫中起重要作用.越来越多研究者认为NKG2D及其配体对肿瘤的早期识别、诊断及治疗研究具有重要意义.本文就NKG2D及其配体的介绍、信号传导、肿瘤免疫,特别是消化系肿瘤中的研究现状和诊治中的应用等方面作一综述.Natural killer group 2D （NKG2D） is a C-type lectin-like activating receptors on natural killer （NK） cells. The ligands for NKG2D are frequently expressed on the surface of inflammatory cells and tumor cells, but are rarely detected in healthy cells and tissues. In recent years, some studies have proved that there is decreased expression of NKG2D but increased expression of its ligands in tumor cells. NKG2D-mediated antitumor response plays an important role in innate immunity. More and more researchers believe that NKG2D and its ligands have great value for early identif ication, diagnosis and treatment of tumors. In this article, we will review recent discoveries concerning the role of NKG2D and its ligands in signal transduction and tumor immunity, especially in digestive system tumors.

关 键 词：NKG2D 消化系肿瘤 免疫监视 免疫逃逸 

分 类 号：R735[医药卫生—肿瘤]