首发抑郁症患者下丘脑及丘脑质子磁共振波谱分析  

Proton magnetic resonance spectroscopy of the thalamus and hypothalamus in patients with first-episode depression

作　　者：杨睿[1] 邬小平[2] 白晓英[1] 宁文德[2] 杨军乐[2] 谢治椽[1] 

机构地区：[1]西安市中心医院精神科,陕西西安710003 [2]西安市中心医院影像中心,陕西西安710003

出　　处：《南方医科大学学报》2009年第12期2442-2445,共4页Journal of Southern Medical University

基　　金：陕西省科学技术研究发展计划项目支持[项目编号:2007K15-7301(18)];同时获西安市科技计划项目支持:(项目编号:YF07143)

摘　　要：目的探讨未用药治疗的首发抑郁症患者下丘脑及丘脑的脑代谢有无异常。方法利用质子磁共振波谱分析技术(1H-MRS)检测30例未用药首发抑郁症患者和30名健康志愿者下丘脑及丘脑的多个代谢指标,包括N-乙酰天门冬氨酸盐(Naa)、胆碱复合物(Cho)、肌酸(Cr)、肌醇(mI)等。结果与对照组相比,患者组下丘脑mI、mI/Cr值下降,左侧丘脑的ml/Cr值下降,右侧丘脑的Cho、ml、ml/Cr值下降,与对照组相比差异有统计学意义(P<0.05)。结论初发抑郁症患者下丘脑、丘脑可能存在肌醇磷酸循环障碍,细胞的渗透压的调节可能存在异常,下丘脑、丘脑ml/Cr代谢异常可能是晚期抑郁症患者的重要生化改变。Objective To investigate the presence of abnormal metabolism in the thalamus and hypothalamus in patients with first-episode depression. Methods Thirty drug-naive patients with first-episode depression and 30 age-matched controls were scanned with proton magnetic resonance spectroscopy （1H-MRS） for Naa, Cho, Cr and mI. Results Compared with the control group, the patients showed significantly reduced mI and mI/Cr of the hypothalamus, reduced mI/Cr of the left thalamus, and lowered Cho, ml, and ml/Cr of the right thalamus （P0.05）. Conclusion Patients with first-episode depression may have myo-inositol and phosphoric acid metabolism disorder in the thalamus and hypothalamus with malfunction of cellular osmotic pressure adjustment mechanism. Abnormal mI/Cr in the thalamus and hypothalamus may represent an important biochemical change in advanced patients with depression.

关 键 词：磁共振波谱学 抑郁症 下丘脑 丘脑 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R445[医药卫生—临床医学]