化生性乳腺癌中基底细胞样标志物的表达及意义  

Expressions of basal-like markers and their significance in metaplastic breast carcinoma

作　　者：王海[1] 冷冬妮[2] 王建东[1] 周航波[1] 姚育英[1] 石群立[1] 周晓军[1] 

机构地区：[1]南京军区南京总医院病理科,江苏南京210002 [2]解放军第454医院病理科,江苏南京210002

出　　处：《诊断学理论与实践》2009年第6期635-638,共4页Journal of Diagnostics Concepts & Practice

基　　金：南京军区南京总医院青年基金课题(Q2008065)

摘　　要：目的:探讨化生性乳腺癌(MBC)中基底细胞样标志物的表达及意义。方法:采用HE、免疫组化(EnVision法)和荧光原位杂交(FISH)方法观察7例MBC,并结合文献进行分析。结果:7例化生性乳腺癌中,3例为鳞状细胞癌,1例为腺鳞癌,1例为梭形细胞化生,2例伴软骨或骨化生。7例免疫标志物检测的阳性率:雌激素受体(ER)、孕激素受体(PR)和HER-2均为0%(0/7),细胞角蛋白5/6(CK5/6)为100%(7/7),细胞角蛋白14(CK14)为71.4%(5/7),表皮生长因子受体(EGFR)为85.7%(6/7),P63为71.4%(5/7)。1例行FISH检测未见HER-2基因明显扩增。结论:MBC具有基底细胞样表型。Objective To study the expressions of basal cell-like markers and their significance in metaplastie breast carcinoma. Methods Seven cases of metaplastic breast carcinoma were studied with HE staining, EnVision immunostaining and fluorescence in situ hybridization （FISH）, and related literatures were reviewed. Results Of these seven cases of metaplastic breast carcinoma, 3 were squamous cell carcinoma, 1 was adenosquamous carcinoma, 1 was carcinoma with spindle cell metaplasia, and 2 were carcinoma with cartilaginous element or osseous element. Immunohistochemically, the positive rates were ER 0%（0/7）, PR 0%（0/7）, HER-2 0%（0/7）, CK5/6 100%（7/7）, CK14 71.4% （5/7）, EGFR 85.7%（6/7）, P63 71.4%（5/7）. FISH test was performed in one case and no apparent amplification of HER-2 gene was seen. Conclusions Metaplastic breast carcinomas has basal cell-like phenotype.

关 键 词：乳腺 化生性癌 基底细胞样型乳腺癌 基底细胞样标志物 诊断 

分 类 号：R737.9[医药卫生—肿瘤]