双酚A对接触男工精液质量的影响  

Effect of bisphenol A on semen quality of exposed workers： a pilot study

作　　者：肖国兵 王仁元 蔡耀章 何国华 周志俊[3] 

机构地区：[1]浙江省宁波市卫生监督所,315010 [2]宁波预防医学会 [3]复旦大学公共卫生学院

出　　处：《中华劳动卫生职业病杂志》2009年第12期741-743,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：目的探讨双酚A（BPA）对接触男工精液质量的影响。方法选择20名接触BPA的工人作为职业接触组，另选择与接触组年龄、职业和体力活动相匹配，但不接触BPA和其他可能损伤生殖功能的物理或化学因素的16名造型工人作为对照组。采集被调查对象的血液，检测其血液中BPA水平，按WHO推荐方法分析精液质量。结果94．4％的接触组工人血液中检出BPA，中位数为101．94μg／L，而对照组仅有18．8％的工人血液中检出BPA，中位数为0μg／L。接触组精子密度[（68．65±44．00）×10^6个／ml]明显低于对照组[（118．56±98．36）×10^6个／ml]，差异有统计学意义（P〈0．05），而其他精液和精子质量指标则未见明显差异。相关分析结果表明，精子快速前向运动与血液中BPA水平呈正相关（r=0．44，P〈0．01），精子正常率与血液中BPA水平呈负相关（r=-0．62，P=0．01）。结论接触BPA可引起男工精子密度降低，BPA可能在一定程度上影响精液质量。Objective To explore the semen quality of the workers exposed to the xenoestrogen bisphenol A（BPA） was explored. Methods A cross-sectional study of 20 BPA exposed and 16 control workers with similar age,physical activities was performed. Tests included quantifying BPA in blood samples and investigating the quantity and quality of semen. Semen parameters were determined with the method recommended by WHO. Results 94.4% exposed workers were found BPA in blood, and the median was 101.94 μg/L. However, only 18.8% control subjects were found BPA in blood, and the median level was 0 μg/L. The sperm density of exposed workers [（68.65±44.00）×10^6/ml] was significantly lower than that of control [（ 118.56± 98.36）×10^6/ml]. Relationship analysis showed the positive relationships （r=0.44, P〈0.01） between the sperm with quick forward progression and BPA level in blood, negative relationships between the percentage of norreal sperm and BPA level in blood （r=-0.62,P=0.01）, Conclusion BPA could affect the sperm density, and may influence the semen quality. More research should be performed on the effect and the mechanism of BPA on man.

关 键 词：酚类 精子 精液 生殖 

分 类 号：R686[医药卫生—骨科学]