血尿酸水平与不同病因分型脑梗死发病及预后的关系  

Study on the relationship among the level of plasma urate and onset and prognosis in cerebral infarction caused by different etiological subtype

作　　者：冯靓[1] 韩钊[1] 张征[1] 臧秋玲[1] 叶祖森[1] 王苹莉[1] 

机构地区：[1]温州医学院附属第一医院脑血管科,浙江温州325000

出　　处：《温州医学院学报》2009年第6期575-578,共4页Journal of Wenzhou Medical College

基　　金：温州市科技局科研基金资助项目(Y2004A014);温州市重大科研资助项目(Y20070038)

摘　　要：目的:探讨高尿酸血症与不同病因分型脑梗死发病的关系;探讨脑梗死急性期血尿酸水平与脑梗死发病后3个月预后的关系。方法:选取在我院住院治疗的脑梗死患者405例。在血尿酸水平与脑梗死发病关系研究中,按照患者是否为动脉粥样硬化性脑梗死进行分组,在预后关系研究中按照3个月随访的mRS评分进行分组。统计方法采用单因素分析和多因素分析相结合的方法,其中多因素分析采用logistic回归分析。结果:与动脉粥样硬化性脑梗死发病有关的因素为年龄、高尿酸血症、高血压、糖尿病,其中,高尿酸血症的OR值为4.764;与脑梗死3个月预后有关的因素为年龄、NIHSS评分和卒中并发症,尽管血尿酸水平在单因素分析时有意义,但在多因素分析时未达到统计学显著性。结论:高尿酸血症是动脉粥样硬化性脑梗死的一个独立危险因素。急性期血尿酸水平尚不能作为脑梗死3个月预后的独立预测因子。Objective：To study the relationship among hyperuricemia and onset of illness in cerebral infarction caused by different etiological subtype.To assess the relationship between 3-month outcome and serum urate level in acute stage of cerebral infarction.Methods： Four hundred and five consecutive patients with cerebral infarction were selected.In the study on the relationship between the level of plasma urate and cerebral infarction,patients were divided into different groups based on whether the etiological subtype was atherosclerotic ischemic stroke,while in study on the relationship of prognosis, patients were divided according to mRS of three months follow-up. Univariate analysis combining multivariate anaiysis was taken as statistical methods, logistic regression analysis was adopted for multivariate analysis. Results： The factors related to the onset of the cerebraI infarcteion atheroslerotic were age, hyperurecemia, hypertension and diabetes meilitus,in which the OR value in hyperuricemia was 4.76. The factors of age, NIHSS and complication of stroke were related to prognosis after the cerebrailinfarction three months later. The level of plasma urate had no statistical significance in multivariate analysis. Conclusion： Hyperuricemia is an independent risk factor for atherosclerotic ischemic stroke. The level of plasma urate in acute stage can not be taken as an indepented predict factor of the outcome after cerebral infarction for three months.

关 键 词：脑梗死 尿酸 动脉粥样硬化 预后 多因素分析 

分 类 号：R743[医药卫生—神经病学与精神病学]