FⅦ活化蛋白酶基因的Marburg Ⅰ型多态性与脑梗死发病的相关性  

Marburg Ⅰ polymorphism of Factor Ⅶ-activating protease and cerebral infarction

作　　者：谭倩[1] 唐华容[1] 刘荣荣[2] 王光平[1] 杨晓苏[3] 陈方平[1] 

机构地区：[1]中南大学湘雅医院血液科,长沙410008 [2]大连医科大学附属第一医院血液科,辽宁大连116011 [3]中南大学湘雅医院神经内科,长沙410008

出　　处：《中南大学学报（医学版）》2009年第12期1171-1175,共5页Journal of Central South University ：Medical Science

摘　　要：目的:探讨FⅦ活化蛋白酶(Factor Ⅶ-activating protease,FSAP)基因的Marburg Ⅰ型多态性与脑梗死发病之间的相关性,并分析FSAP的Marburg I型多态性是否为脑梗死的危险因子之一。方法:应用单链构象多态性PCR技术(SSCP-PCR),对159例临床确诊的脑梗死患者及179例年龄、性别相匹配的无血栓性疾病病史志愿者的FSAP基因进行多态性分析。结果:FSAP基因表型在病例组及对照组中均为野生型纯合子,未检测到Marburg Ⅰ型突变型。发现1例FSAP基因点突变(C1815T)。结论:FSAP基因的Marburg Ⅰ型多态性与脑梗死发病可能无相关性。Objective To determine the relation between Marburg I polymorphism of FactorⅦ-activating protease（FSAP）and cerebral infarction,and to analyze whether it is one of the risk factors of cerebral infarction.Methods Single strand conformation polymorphism-polymerase chain reaction（SSCP-PCR）was applied for the polymorphism analysis of FSAP in 159 patients with cerebral infarction and 179 non-cerebral infarction subjects.Results The phenotypes of FSAP in both the patients and the control subjects were wild type GG;no mutant of Marburg I was found.But a new gene mutation was tested,which had not been reported,requiring further investigation.Conclusion Marburg I polymorphism of FSAP may not be associated with cerebral infarction.

关 键 词：FⅦ活化蛋白酶 MARBURG Ⅰ型多态性 脑梗死 单链构象多态性PCR 

分 类 号：R743.3[医药卫生—神经病学与精神病学]