线粒体醛脱氢酶对心脏保护作用的研究进展  

Progress of mitochondrial aldehyde dehydrogenase in cardioprotection

作　　者：何岚[1] 彭军[1] 

机构地区：[1]中南大学药学院药理学系,湖南长沙410078

出　　处：《中国药理学通报》2009年第12期1548-1551,共4页Chinese Pharmacological Bulletin

基　　金：全国优博专项基金资助项目(No2007B7)

摘　　要：线粒体醛脱氢酶(ALDH2)是醛脱氢酶的亚型之一,具有脱氢酶和酯酶等多种酶功能。体内乙醇、氨基酸、生物胺、维生素、类固醇及脂质的代谢过程中会产生众多醛类物质。ALDH2在辅助因子NAD(P)+的参与下将醛类物质脱氢成为相应的羧酸,对减轻醛类物质对机体的毒性作用具有重要意义。ALDH2发挥酯酶功能则不需要辅助因子,可将羧酸酯或者其他酸转化为相应的羧酸和醇。近年的研究表明,ALDH2酶活性的下降将加重酒精、缺血等多种因素引起的心肌损伤和促进硝酸甘油耐受的发生,因此针对ALDH2开发和研制特异性激动剂,将为心脏疾病的药物防治提供新思路。Mitochondrial aldehyde dehydrogenase（ALDH2）,one of the isoforms of aldehyde dehydrogenase,has multiple enzymatic functions including the activity of dehydrogenase and esterase.The metabolisms of ethanol,amino acids,biogenic amine,vitamin or steroid in the body produce various substances of aldehyde.With the help of co-factor NAD（P）^＋,ALDH2 can convert aldehydes into corresponding carboxylic acid,which plays a key role in reducing toxic effects of aldehydes on the body.It does not need co-factor when ALDH2 works as esterase.It can convert carboxylic ester or other acids into corresponding carboxylic acids or alcohols.Recently,it has been shown that the decrease of ALDH2 activity exacerbates multiple factors（such as ethanol,ischemia）-induced myocardial injury and accelerates the development of nitroglycerin tolerance.Therefore,the development of specific agonists of ALDH2 may provide a novel approach to the therapy and prevention of heart diseases.

关 键 词：线粒体醛脱氢酶 酒精性心肌病 缺血/再灌注损伤 硝酸甘油耐受 4-羟基壬烯醛 丙二醛 

分 类 号：R-05[医药卫生] R329.24