大黄素药理作用的分子机制研究进展  

Research progress in molecular mechanism of the pharmacological actions of emodin

作　　者：刘晗[1] 高云[1] 

机构地区：[1]南昌大学基础医学院生理学教研室,江西南昌330006

出　　处：《中国药理学通报》2009年第12期1552-1555,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30860333);江西省自然科学基金资助项目(No2007GZY1002)

摘　　要：大黄素是中药大黄的主要有效单体,具有多种药理作用,具有较高的临床应用价值。近年来国内外有关大黄素药理作用分子机制的研究较多,特别对其消炎、抗肿瘤的作用高度关注。这些作用主要是通过改变离子浓度及转运、抗氧化和自由基、影响炎症因子的分泌和酶活性、细胞凋亡等途径实现的。该文对此进行了总结,希望能为其实际应用提供理论依据。Emodin is the main effective monomer of Rhubarb,which has a variety of pharmacological actions and valuable clinical applications.Recently,there are many reports about molecular mechanisms of emodin pharmacological actions,and they givehighly attention on the dephlogisticating and antineoplastic effects.These effects are achieved through affecting the concentration and transportation of ions,resisting of oxidation and free radical,and affecting the secretion of inflammatory factor and the enzyme activity and apoptosis and so on.This article summarizes the reports and hopes to provide theoretical basis for the practical application.

关 键 词：大黄素 药理作用 分子机制 离子转运 炎症因子 细胞凋亡 

分 类 号：R-05[医药卫生] R282.71