脊髓损伤动物模型的复制及其实验治疗学应用  

Duplication of animal models for spinal cord injury and its application in experimental therapeutics

作　　者：顾兵[1] 张政 李华南[2] 孟玮[1] 余日跃 

机构地区：[1]江西科技师范学院药学院,江西南昌330013 [2]江西中医学院附属医院,江西南昌330006

出　　处：《中国药理学通报》2009年第12期1559-1562,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30960448);江西省卫生厅科技计划资助项目(No20072036);江西省教育厅科技计划资助项目(NoGJJ09546)

摘　　要：脊髓损伤的机制和神经损伤后的修复治疗是当前神经科学研究的热点。动物模型的复制为开展脊髓损伤的实验治疗学研究起了很关键的作用。该文就国内外已经建立的脊髓挫伤、压迫损伤、横断损伤、缺血损伤、牵张损伤和化学损伤等模型的进展作系统综述,同时列举了这些模型在实验治疗学上的应用,为实验性新药的筛选提供科学指导。The mechanism of spinal cord injury and repair therapy after nerve injury is currently a hotspot of neuroscience research.Duplicating animal models plays a key role in experimental therapeutics of spinal cord injury.This review systematically describes the progress in animal models for spinal cord injury including contusion,compression,transection,ischemic,distraction and chemical-mediated injury,which have been established at home and abroad.Based upon the aforementioned models,some applications in experimental therapeutics are simultaneously enumerated.All these information provides scientific guidance for the experimental novel drugs＇screening.

关 键 词：脊髓损伤 动物模型 挫伤模型 压迫损伤模型 横断损伤模型 实验治疗学 

分 类 号：R-05[医药卫生] R363-332