子宫动脉栓塞治疗子宫肌瘤的中远期随访研究  

Uterine artery embolization for treatment of leiomyoma： long term results and effects on outcomes

作　　者：纪新强[1] 李子祥[1] 尹吉梅[2] 赵延吉[2] 段玉英[1] 

机构地区：[1]青岛大学医学院附属医院妇科,山东青岛266003 [2]山东省莱州市人民医院

出　　处：《中国医师杂志》2009年第12期1620-1623,共4页Journal of Chinese Physician

基　　金：山东省教育厅科研基金项目（J99K01）

摘　　要：目的探讨子宫动脉栓塞术（UAE）治疗子宫肌瘤的疗效及安全性。方法对185例子宫肌瘤患者进行UAE治疗，经1～6年随访，观察子宫肌瘤体积变化及临床症状改善情况，其中44例检测血中的卵巢激素水平，评价内分泌功能改变。结果185例患者均行双侧子宫动脉栓塞，对292枚肌瘤进行1～6年的随访。栓塞后1～9个月肌瘤体积缩小最明显，栓塞1年后，肌瘤体积几乎不再缩小。黏膜下肌瘤缩小程度大于肌壁间肌瘤，肌壁间肌瘤大于浆膜下肌瘤。较大的肌瘤（体积≥150cm^3）的缩小程度小于体积较小的肌瘤。月经量增多、贫血和肌瘤所致的压迫症状均缓解。栓塞后血清卵巢激素水平无变化。UAE后无严重并发症发生。结论UAE治疗子宫肌瘤的疗效确切，使肌瘤体积显著缩小，能有效地控制临床症状，无严重并发症。Objective To evaluate the effects and safety of uterine artery embolization for uterine leiomyoma. Methods Total of 185 patients with uterine leiomyoma were treated by UAE. They were followed for one to 6 years to observe the changes of leiomyoma size and improvement in clinical symptoms. Ovarian function was evaluated in 44 eases. Results Bilateral embolization of uterine arteries was performed in 185 patients. Follow-up of 1 - 6 years for 292 leiomyoma indicated that one to 9 months after embolization, shrinkage of leiomyoma size was the most significant factor. One year after embolization, leiomyoma sizes decreased a little. Shrinkage of submucous leiomyoma was more significant than that of intratumoral one, and the latter was more significant than subserous one. Shrinkage of leiomyoma with large size （ volume≥ 150cm^3 ） was less than that of small one. Menorrhagia, anemia and pressure symptoms were all resolved. There was no significant difference between preand post embolization ovarian hormone level. Conclusions The significant reduction in leiomyoma volume and resolution of clinical symptoms confirmed that the treatment validity of symptomatic leiomyomas by UAE. UAE is an effective therapeutic procedure which has no adverse effect on the ovarian function.

关 键 词：栓塞 治疗性 子宫肿瘤/治疗 平滑肌瘤/治疗 

分 类 号：R737.33[医药卫生—肿瘤] R749.3[医药卫生—临床医学]