我国4城市学龄前儿童血清维生素B_(12)营养状况调查  

VITAMIN B_(12) NUTRITIONAL STATUS IN PRESCHOOL CHILDREN IN CHINA

作　　者：李宁[1] 黎海芪[1] 魏庄[2] 张红忠[3] 廖艳[1] 杨绍萍 

机构地区：[1]重庆医科大学附属儿童医院儿童保健科,重庆400014 [2]首都医科大学附属北京儿童医院保健中心,北京100045 [3]珠海市妇幼保健院,519000 [4]武汉市妇幼保健院,430040

出　　处：《营养学报》2009年第6期527-531,共5页Acta Nutrimenta Sinica

基　　金：中国营养学会营养科研基金(No2006060)

摘　　要：目的了解我国学龄前儿童血清维生素B12(VB12)的营养状况。方法描述性流行病学研究;对来自北京、珠海、重庆、武汉4城市2002名2岁～7岁儿童进行体格检查、膳食调查、血常规筛查及血清VB12水平测定。结果⑴2002名儿童平均血清VB12水平为775pg/ml,市区(835pg/ml)高于郊区(720pg/ml,P<0.001),其中北京840pg/ml、珠海772pg/ml、重庆756pg/ml、武汉735pg/ml,地区间差异显著(P<0.001);⑵学龄前儿童平均血清VB12水平在各年龄组间有明显差异(P<0.05),无性别差异(P>0.05);⑶2002名儿童血清VB12缺乏(血清VB12<200pg/ml)检出率为1.5%,边缘性缺乏(血清VB12200pg/ml～300pg/ml)检出率为3.2%,市区儿童血清VB12缺乏和边缘性缺乏检出率(3.6%)低于远郊(5.9%,P<0.05)。其中北京、珠海、重庆、武汉4城市儿童血清VB12缺乏和边缘性缺乏检出率分别为0.4%、3.5%,0.2%、3.0%,0.2%、1.9%,5.2%、4.6%;⑷儿童血清VB12水平主要受膳食VB12摄入量的影响(P<0.001)。2002名儿童平均膳食VB12摄入量为2.2μg/d,市区(2.4μg/d)高于郊区(2.0μg/d,P<0.05)。北京、珠海、重庆、武汉4城市儿童平均膳食VB12摄入量分别为2.8、2.6、1.9、1.6μg/d,差异显著(P<0.001)。结论⑴我国学龄前儿童存在VB12缺乏,以边缘性缺乏为主。⑵学龄前儿童血清VB12水平高于成人,血清VB12水平有随年龄增长而降低的趋势,提示血清VB12水平存在年龄差异。⑶学龄前儿童膳食VB12摄入量的高低决定血清VB12水平的高低。Objective：To explore the levels of serum VB12 of preschool children of 4 cities in China. Method Cross-sectional analysis was applied. From May 2007 to October 2008,the weight,height and complete blood count （CBC） were studied in 2002 children aged 2 to 7 years from the four cities（Bejing,Zhuhai, Chongqing,Wuhan）in China.The concentrations of serum VB12 and the dietary surveys were evaluated.Results The average level of serum VB12 for the preschool children in 4 cities was 775pg/ml,in which for the preschool children in urbans were higher than those in suburbs（P〈0.001）.The concentrations of serum VB12 of preschool children in Beijing,Zhuhai,Chongqing,Wuhan were 840, 772, 756 and 735 pg/ml respectively. 1.5% preschool children serum VB12 below 200 pg/ml（as VB12 deficiency）,and 3.2% preschool children 200～300 pg/ml（as VB12 marginal deficiency）.The prevalence of VB12 deficiency and marginal deficiency of preschool children in urbans was lower than that in suburbs（P〈0.05）,and was 0.4% and 3.5%,0.2% and 3.0%,0.2% and 1.9%, 5.2% and 4.6%,in Beijing,Zhuhai,Chongqing,and Wuhan respectively. There were significant differences among 4 cities（P〈0.001）. The dietary intake and nutritional condition of VB12 of the children ware also different in 4 cities. Conclusion Low serum VB12 of preschool children was prevalent in China. The consumption of VB12 in animal foods determineed the levels of serum VBl2 for the preschool children.

关 键 词：维生素B12 儿童 学龄前 营养调查 

分 类 号：R151[医药卫生—营养与食品卫生学]