高强度聚焦超声联合肝动脉介入化疗治疗45例中、晚期肝癌的临床研究  

High intensity focused ultrasound combined with transcatheter arterial chemoembolization in patients with hepatoma

作　　者：庄兴俊[1] 欧娟娟[1,2] 高云姝[1] 高百春[1] 顾军[1] 

机构地区：[1]解放军401医院综合科,青岛266071 [2]第三军医大学

出　　处：《重庆医学》2010年第1期46-47,共2页Chongqing medicine

摘　　要：目的探讨利用高强度聚焦超声(HIFU)联合肝动脉介入化疗(TACE)对中、晚期肝癌进行综合治疗的疗效。方法将确诊的中、晚期原发性肝癌患者45例分为A、B组,A组23例先行TACE后再行HIFU治疗(治疗剂量20s,40s,8次,1次/周,总疗程3～4周;B组22例单纯行HIFU治疗,治疗剂量同A组。比较两组的不良反应和近期疗效。结果A组完全缓解(CR)2例,部分缓解(PR)17例,CR+PR 82.6%;B组CR 0例,PR13例,CR+PR 59.1%,两组比较差异有统计学意义(χ2=3.97,P=0.03)。肝脏急性不良反应A组1级3例,2级1例,无3、4级不良反应。B组1级2例,无2级以上不良反应。结论HIFU联合TACE能提高中、晚期肝癌的疗效,不增加不良反应。Objective To investigate the therapeutic alliance effect of high intensity focused ultrasound （HIFU） and transcatheter arterial chemoembolization（TACE） in treating hepatoma. Methods Forty five patients were devided into two groups A and B. The patients in group A were treated by TACE following with HIFU treatment 3-4 times,and the patients in group P, were treated only by HIFU with the same energy dose. To observe the therapeutic effects and side effects. Results In group A,there were 2 patients reaching CR and 17 reaching PR,CR ＋ PR 82.6% ;in group B,there were 0 CR and 13 PR,CR ＋ PR 59.1% ,the difference between two sets was significant（X2 = 3.97,P=0.03 ）. In group A,there were 3 patients with Class I adverse effect of liver and Ⅰ with Class Ⅱ ,there was no patient with Class Ⅲ or Class Ⅳ. In group B,there were only 2 with Class I . Conclusion Treatment of HIFU combined with TACE can benefit the patients of hepatoma without additional side effects.

关 键 词：肝癌 高强度聚焦超声 肝动脉介入化疗 

分 类 号：R735.7[医药卫生—肿瘤] R730.53[医药卫生—临床医学]