抗癌新药奥沙利铂治疗晚期大肠癌  

OXALIPLATIN,A NEW ANTICANCER DRUG,IN TREATMENT OF ADVANCED COLORECTAL CANCER

作　　者：张湘茹[1] 孙燕[1] 李青[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院

出　　处：《中国新药杂志》1998年第4期266-269,共4页Chinese Journal of New Drugs

摘　　要：目的：阐述奥沙利铂的药理学和临床研究概况。方法：综述了１９９３～１９９７年的有关奥沙利铂的研究进展。结果：奥沙利铂抗瘤谱与顺铂不同，与顺铂无交叉耐药性，单药或与氟脲嘧啶／甲酰四氢叶酸钙联合治疗晚期大肠癌有较好疗效，而毒副反应较顺铂轻。结论：奥沙利铂是一个有前途的药物。OBJECTIVE:To brief the pharmacological and clinical studies of oxaliplatin.METHODS:The advances in the study of oxaliplatin were reviewed.RESULTS:Oxaliplatin has an anticancer spectrum different from cisplatin and has no crossresistance with cisplatin.A better result has been obtained in treatment of advanced colorectal cancer with oxaliplatin alone or in combination with 5fluorouracil and folinic acid with mild ADRs in comparison with cisplatin.CONCLUSION:Oxaliplatin is a promising anticancer drug in chemotherapy but further studies seem to be needed.

关 键 词：奥沙利铂 顺铂 大肠癌 药理 治疗 

分 类 号：R735.340.5[医药卫生—肿瘤] 979.1[医药卫生—临床医学]