胃癌高发区cagA^(+)幽门螺杆菌的感染  

Infection ofH.pyloriwith cagA^(+) strain in a highrisk area of gastric cancer

作　　者：张联[1] 江骥[2] 潘凯枫[1] 刘伟东[1] 马峻岭 周彤 Perez-Perez GI Blaser Mj 昌云生 游伟程[1,6] 

机构地区：[1]北京医科大学临床肿瘤学院 [2]北京协和医院 [3]山东省临朐县卫生局 [4]潍纺市医药研究所 [5]美国Vanderbilt大学医学院传染病学系 [6]美国国立癌症研究所

出　　处：《华人消化杂志》1998年第1期40-41,共2页

摘　　要：目的研究胃癌高发区不同人群幽门螺杆菌（Ｈｐ）ｃａｇＡ＋亚型感染状况，探讨ＨｐｃａｇＡ＋亚型感染与胃癌高发流行的关系．方法用ＥＬＩＳＡ方法检测了全部受检者的抗Ｈｐ抗体及抗ｃａｇＡ抗体，并用１３Ｃ尿素酶呼吸实验（１３Ｃ－ＵＢＴ）方法检测了７０名儿童Ｈｐ感染状况．结果胃癌高发区成人Ｈｐ感染率为７４７％，儿童Ｈｐ感染率为６８６％；成人ｃａｇＡ＋亚型感染率为６５％，儿童为７１４％．７７名癌症患者的Ｈｐ和ｃａｇＡ＋亚型感染率均为５９７％，其中胃癌患者（ｎ＝３８）Ｈｐ和ｃａｇＡ＋亚型感染率分别为５０％和５５３％，均低于其他癌症患者（ｎ＝３９）的感染率（６９２％和６４１％）．结论胃癌高发区成人、儿童及癌症患者ＨｐｃａｇＡ＋亚型感染率相当高，表明Ｈｐ感染，尤其是ｃａｇＡ＋的Ｈｐ感染与当地胃癌高发有明显的关系．IM To determine the seroprevalence of Helicobacter pylori (Hp) with cagA+ strain in different population at a high risk area of gastric cancer (GC), and evaluate whether infection of Hp with cagA+ is associated with the development of GC. METHODS Using ELISA to detect IgG and IgA to antiHp and IgG to antiCagA antigen, we examined the total 368 serum samples from Linqu County (mortality of GC=43/100 000). The children were also examined by 13Curea breath test (13CUBT) to confirm Hp infection. RESULTS The Hp seropositive rates of adults and children were 747% and 686%, and cagA+ were 65% and 714%, respectively. However, the seropositive rates of Hp and cagA+ were similar (597%) in 77 cancer patients. CONCLUSION The seroprevalence of Hp with cagA+ strain is significantly high in the population at a high risk area of GC. The infection of Hp with cagA+ may be a key factor of development of GC..

关 键 词：胃肿瘤/微生物学 螺杆菌.幽门 螺杆菌感染/并发症 

分 类 号：R735.2[医药卫生—肿瘤]