河北省赞皇县胃癌高发区和相对低发区居民饮食问卷调查  

Effects of Methylmercury on Mitochondrial DNA Polymerases of Ovary of Mice

作　　者：张祥宏[1,2,3] 张振国 赵文元[1,2,3] 王俊灵 严霞 谢同欣[1,2,3] 米建民 卜玉华[1,2,3] 孙旭明 曹文军 王会艳[1,2,3] 边林 王凤荣[1,2,3] 三角顺一 青木一雄[1,2,3] 

机构地区：[1]河北医科大学病理研究室 [2]河北省赞皇县医院 [3]日本大分医科大学

出　　处：《中国公共卫生学报》1998年第4期246-247,共2页

摘　　要：以随机抽样问卷调查方法，就家庭经济情况、饮食习惯、营养状况、家族史等方面的２１７项子内容对河北省赞皇县境内胃癌高发区和相对低发区１１０１名３０岁以上居民进行了对比分析。结果发现，赞皇县胃癌高发区居民年均收入较相对低发区低，调查对象有胃癌及胃溃疡家族史者明显高于相对低发区；高发区男性居民有吸烟习惯者达６９７％，明显高于相对低发区（４５８％）；高发区男性居民喜食热烫食物和缺乏营养平衡意识的比率明显高于相对低发区。? In order to understand the effects of methylmercury on mitochondrial DNA polymerase of ovary of mice,mitochondria of ovary of mice were seperated.The crude extract of DNA polymerase was made by ultra centrifugation.The activity of DNA polymerase was measured by DNA replication in vitro.Results showed that methylmercury could affect the activity of mitochondrial DNA polymerase of ovary of mice.The activity of DNA polymerase was increased with doses of administration enlenged and there was dosedependent relationship.It indicated the activity of DNA polymerase related to the DNA demage repaire synthesis occured.

关 键 词：胃癌 生活习惯 饮食 调查 流行病学 

分 类 号：R735.201[医药卫生—肿瘤]