C-erbB-2原癌基因产物在胃癌中的表达  

Expression of C-erbB-2 Oncoprotein in Gastric Carcinoma

作　　者：王慧萍[1] 丁伟[1] 严丽萍 

机构地区：[1]浙江医科大学附属第一医院,杭州310003

出　　处：《浙江肿瘤》1998年第3期166-167,共2页

摘　　要：[目的]控讨C－erbB－2基因产物表达在胃癌的进展、生物学行为及预后判断中的作用。[方法]应用免疫组织化学方法研究C－erbB－2在63例胃癌标本中的表达。[结果]C－erbB－2原癌基因产物在进展期胃癌组、伴有淋巴结转移组及体有血管或神经侵犯组的阳性表达率分别为64．9％，74．2巩和66．7％。C－erbB－2表达与胃癌的分级和分化程度，淋巴结转移等有关（P＜0．05）。[结论]C－erbB－2原癌基因检测可作为胃癌生物学行为和胃癌预后判断的重要指标。[Purpose]To investigate the role of oncogene C－erbB－2 in gastric carcinoma [Method]Expression of C－erbB－2 in 63 cases of gas－tric adenocarcinoma were studied by immunohistochemical technique [Results]Positive rates of C－erbB－2 were 64.9%,74.2% and 66.7% re－spectively in advanced cancer,cancer with lymph nodes metastasis and cancer with vascular or neural invasion Close relationship was observed be－tween C－erbB－2 and the grade of xstage of the tumor[Conclusion] C－erbB－2 might be served as maker for the evaluation of biological behavior and prognosis in gastric carcionoma

关 键 词：胃肿瘤 C-ERBB-2 免疫组化 癌基因 

分 类 号：R735.202[医药卫生—肿瘤]