预缺血对氨基甲酸乙酯麻醉家兔缺血/再灌注心肌的保护  

Protection ischemic preconditioning on the ischemia-reperfused myocardium in urethane-anesthetized rabbits

作　　者：丁延峰[1,2,3,4] 牛新清[1,2,3,4] 秦永杰[1,2,3,4] 周素凤[1,2,3,4] 李东亮[1,2,3,4] 何瑞荣[1,2,3,4] 

机构地区：[1]新乡医学院生理教研室 [2]新乡医学院第二附属医院 [3]新乡医学院电教科 [4]河北医科大学生理研究室

出　　处：《新乡医学院学报》1998年第2期105-107,共3页Journal of Xinxiang Medical University

摘　　要：目的探讨预缺血对长时间缺血／再灌注心肌的保护作用。方法在氨基甲酸乙酯麻醉家兔心肌模型上，观察缺血／再灌注组和预缺血组对血流动力学、心功能、心肌耗氧量、心外膜电图和心肌梗塞范围的影响，并对结果进行统计分析。结果两组在缺血／再灌注过程中，血流动力学，心功能，心肌耗氧量均明显持续性降低，且两组间心肌耗氧量存在明显差异；心外膜电图ＳＴ段在缺血过程中明显抬高；缺血／再灌注组和预缺血组的心肌梗塞范围分别为３２．３％和２１．６％，有明显差异（Ｐ＜０．０１）。结论预缺血可降低心肌耗氧率，减轻心肌损伤。Objective To research the protection on myocardium with more prolonged ischemia-reperfusion provided by ischemic preconditioning in urethane-anesthetizied rabbits.Methods The effects of ischemia-reperfusion group and ischemic preconditioning group on the hemodynamics, cardic function, myocardial oxygen consumption ,epicardial electrographic,infarct size were examined in urethane-anesthetized rabbit models.the results were analysized by statistic method.Results In the course of ischemia(30min)/reperfusion(180min),all hemodynamic parameters,cardiac function and myocardial oxygen consumption were decreased progressively significantly, while myocardial oxygen consumption in the both groups showed difference(P<0.05).The epicardial electrogrophic ST-segment during myocardial ischemia were markedly increased.The myocardial infarct size of the left ventrical in ischemia-reperfusion group and ischemic preconditioning group were 32.2% and 21.6% respectively, its had significant difference(P<0.01).Conclusion Ischemic preconditioning could decrease myocardial oxygen consumption and reduce injury of myocardium and it provides the cardioprotection during ischemia-reperfusion. 

关 键 词：缺血/再灌注 预缺血 心肌梗塞 氨基甲酸乙酯 

分 类 号：R542.22[医药卫生—心血管疾病]