齐墩果酸结构修饰及抗肿瘤活性的研究进展  

Progress in Research of Structure Modification and Antitumor Activity of Oleanolic Acid

作　　者：郑开波[1] 毛海立[1] 孙成斌[1] 杨再波[1] 

机构地区：[1]黔南民族师范学院化学与化工系,贵州都匀558000

出　　处：《黔南民族师范学院学报》2009年第6期11-14,共4页Journal of Qiannan Normal University for Nationalities

摘　　要：在植物来源的活性先导物的基础上,研究其化学结构与生物活性的关系,进而进行化学修饰研究,以提高化合物的活性和降低毒性是研制新药的一条有效途径。齐敦果酸属于五环三萜类化合物,广泛存在于自然界中,具有多种显著的生物活性,是一种具有开发潜力的先导化合物。本文综述了近年来齐墩果酸结构修饰及抗肿瘤活性的研究进展。In order to improve activity and decrease toxicity, searching for lead compounds with biological activity existing in the nature and modifying their structures are important means of innovation of new drugs. Oleanolic acid belongs to triterpene acids which have numerous pharmacological activities and widely present in food, medicinal herbs and other plants. Here a brief introduction of the recent progresses on structural modification and antitumor activities of Oleanolic acid derivatives are given out.

关 键 词：齐敦果酸 结构修饰 抗肿瘤活性 

分 类 号：R914[医药卫生—药物化学]