髂内动脉-前列腺动脉化疗栓塞治疗晚期前列腺癌  

Intra-iliac arterial prostatic arterial chemo-embolization in the treatment of advanced prostate cancer

作　　者：黄恒海 薛元领 黄志红 郑赓唐 

机构地区：[1]梧州市工人医院泌尿外科,广西543001

出　　处：《中国临床新医学》2009年第12期1257-1259,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西壮族自治区梧州市基金项目(合同编号:200501044)

摘　　要：目的探讨经髂内动脉-前列腺动脉化疗栓塞晚期前列腺癌的疗效。方法对22例晚期前列腺癌患者其中C1期5例,C2期7例,D1期8例,D2期2例,共行25次介入治疗。所用药物剂量分别是:卡铂400mg,丝裂霉素20mg,表阿霉素50mg,长春新碱1mg;栓塞剂选用明胶海绵和碘甘油。结果22例患者自治疗后第1周,病人均出现前列腺质地变软和体积缩小;第2～3周后体积缩小20%～40%;3例术后有神经合并症;1例臀部皮肤组织缺血坏死;8例于化疗栓塞2～3周后行经尿道前列腺汽化电切术。随访5～36个月,尿流率明显改善,残尿量减少或消失。结论经导管双侧髂内动脉超选择(前列腺动脉)化疗栓塞治疗晚期前列腺癌疗效肯定,为综合治疗晚期前列腺癌增加了新的治疗手段,尤其是对非雄性激素依赖性前列腺癌或内分泌治疗无效者更有意义。Objective To study the effect of trans-intra-iliac arterial prostatic arterial chemo- embolization in the treatment of advanced prostate cancer. Methods The therapy was performed in 22 patients with advanced prostate cancer for 25 times. Five cases were in stage C1 ;7 in stage C2;8 in stage D1 ;2 in stage D2. The drug dose was CBP 400 mg, MMC 20 mg, epirubicin 50 mg, VCR 1.0 mg and the embolic agent was gelfoam. Results After one week of the therapy, the symptoms of all the patients were reheved and their prostates got softened and regressed. After 2 ~ 3weeks of the therapy, the regression rate was 20% -40%. The neuro-complications occurred in 3 cases. And 8 cases were treated with urethroelectrotomy after embolization. The follow up time was 5 - 36 months. Results showed their urinary fllow rate was improved and residual urine volume diminished or eliminated. Conclusion Transcathter bilateral intra-iliac superselective chemo-embolization has a positive effect on advanced prostate cancer. It has provided a new method for the comprehensive treatment of advanced prostate cancer, especially for those which belong to androgenic-hormone dependent type, or those which are non-sensetive to the endocrine treatment.

关 键 词：前列腺癌 介入性化疗 栓塞 髂内动脉-前列腺动脉 

分 类 号：R737.25[医药卫生—肿瘤]