肝硬化患者肺泡-动脉血氧分压差的检测及临床意义  

Clinical significance of detecting A aDO 2 in patients with cirrhosis

作　　者：陈远存[1] 何建猷[1] 周宇[1] 袁汉尧[1] 

机构地区：[1]广东医学院附属医院

出　　处：《广东医学院学报》1998年第3期195-197,共3页Journal of Guangdong Medical College

摘　　要：目的：了解肝硬化患者肺泡－动脉血氧分压差（Ａ－ａＤＯ２）值，探讨其梯度与疾病发展、变化的关系。方法：用ＩＬ－１４００型全自动血气分析仪，检测１０５例肝硬化患者与３０例对照组Ａ－ａＤＯ２值，并进行统计学处理。结果：肝硬化组１０５例Ａ－ａＤＯ２平均值为（７．１±３．７）ｋＰａ，代偿期为（５．１±２．５）ｋＰａ，失代偿期为（７．５±３．１）ｋＰａ；对照组为（２．７±１．４）ｋＰａ，肝硬化各组Ａ－ａＤＯ２平均值与对照组比较均有显著性差异（Ｐ＜０．０１）。住院期间病情恶化和死亡病例Ａ－ａＤＯ２梯度也明显高于各组（Ｐ＜０．０１）。以对照组ｘ＋ｓ为临界值，则肝硬化患者Ａ－ａＤＯ２在代偿期、失代偿期阳性率分别为７３．１％和９７．５％，全组平均为８６．６％。结论：Ａ－ａＤＯ２值增大是肝硬化普遍特征，其梯度与疾病发展、恶化有关。Objective:To study the relationship between a change in alveolar arterial oxygen gradient(A aDO 2)and an advance in the condition of patients with cirrhosis.Methods:The value of A aDO 2 was detected by using automatic gas blood analyzing instrument(Type IL 1400) in 105 cirrhosis patients and 30 noncirrhosis patients.and the results of two groups were compared with ANOV.Results:The mean value of A aDO 2 was 7.1±3.7kPa, 5.1± 2.5 kPa in cirrhosis without ascites,7.5±3.1kPa in cirrhosis with ascites,and 2.7±1.4kPa in noncirrhosis respectively.The values of A aDO 2 in these groups were all singificantly higher than those of noncirrhosis group( P< 0.01).In the patients whose condition deteriorated and who died,the value was obviously higher than that of any other group ( P< 0.01).The positive rate of A aDO 2 in cirrhos is with or without ascites was separately 73.1% and 97.5%, and there is clear difference between the two groups( P< 0.01).Conclusions:The increasing A aDO 2 is a popular characteristic of cirrhosis.The value of A aDO 2 is related with the patients' condition.It may be considered as a clinical objective indicator in examining cirrhosis.

关 键 词：肝硬化 肺泡 动脉 血氧分压差 A-aDO2 

分 类 号：R575.2[医药卫生—消化系统]