肝衰竭患者并发真菌败血症21例  

Liver failure complicated by fungous septicemia in 21 patients

作　　者：苏海滨[1] 王慧芬[1] 林芳[1] 许海苗[1] 赵鸿[1] 李雷[1] 闫涛[1] 牟劲松[1] 李晨[1] 

机构地区：[1]解放军302医院肝衰竭治疗研究中心,北京100039

出　　处：《军医进修学院学报》2010年第1期16-18,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的回顾性分析我院肝衰竭患者并发真菌败血症的临床特点。方法以1986年1月-2006年6月收治的肝衰竭患者,血培养有真菌生长者为研究对象。结果符合真菌感染诊断509例,其中发生真菌败血症者共21例(4.13%),60岁以上16例(76.19%),住院天数平均42.5d。给予抗真菌治疗后治愈5例,好转4例,死亡和/或无效12例。结论真菌败血症多发生于基础疾病重、免疫力低下的肝衰竭患者,死亡率高。其主要病原菌为酵母菌属。延误诊断、治疗不正确以及疗程不足、原发病严重的病例预后差。Objective To analyze the characteristics of patients with liver failure complicated by fungous septicemia. Methods Growth of fungus was observed in patients with liver failure admitted to our hospital in January 1986-June 2006. Results Of the 509 patients, 21 （4.13%）, including 16 over the age of 60 years, were diagnosed with fungous septicemia. Their average hospital stay time was 42.5 days. After treatment with antifungal agents, complete recovery was achieved in 5 patients, improvement in 4 patients, death and/or no improvement in 12 patients, respectively. Conclusion Fungous septicemia mainly occurs in immunocompromised patients with liver failure with a high mortality. Delayed diagnosis, incorrect treatment, and inadequate therapy time of the disease would lead to a poor prognosis.

关 键 词：真菌 真菌血症 感染 肝功能衰竭 急性 

分 类 号：R575.3[医药卫生—消化系统] R714.627[医药卫生—内科学]