飞行人员代谢综合征患者胰岛素受体第8外显子NsiⅠ位点基因多态性研究  

Exon 8 Nsi I site polymorphisms of insulin receptor gene in aircrews with metabolic syndrome

作　　者：刘红巾[1] 蔡庆[2] 占志[2] 徐先荣[1] 付兆君[1] 程军[1] 李林[1] 

机构地区：[1]空军总医院全军航空病研究中心,北京100142 [2]空军总医院分子生物学研究中心,北京100142

出　　处：《军医进修学院学报》2010年第2期111-113,共3页Academic Journal of Pla Postgraduate Medical School

基　　金："十一.五"全军医药卫生科研计划课题资助 (08G045)~~

摘　　要：目的研究胰岛素受体(INSR)基因多态性与飞行人员代谢综合征(MS)的相关性。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)和基因测序技术检测38名飞行人员MS患者和50名正常健康飞行人员INSR第8外显子NsiⅠ位点基因多态性。结果INSR第8外显子NsiⅠ位点的基因型和等位基因在飞行人员MS组和正常健康对照组存在统计学差异,INSR基因N2等位基因频率在MS组高于对照组(P<0.01)。结论INSR第8外显子NsiⅠ位点基因多态性与飞行人员MS相关,N2等位基因可能是一个易感基因。Objective To study the correlation between polymorphisms of insulin receptor （INSR） gene and metabolic syndrome （MS） in aircrews. Methods Genotypes of the INSR gene exon 8 Nsi I site in 38 aircrews with MS and 50 health controls were assayed by polymerase chain reaction-restricted fragment length polymorphism and gene sequencing. Results A statistical difference was found in genotypes and allele frequencies of INSR gene exon 8 Nsi I site in aircrews with MS and health controls. The N2 allele frequency of INSR gene was higher in aircrews with MS than in healthy controls （P〈0.01）. Conclusion Polymorphisms of INSR gene exon 8 Nsi I site are associated with MS in aircrews, The N2 allele of INSR gene may be one of the susceptible genes in aircrews with MS.

关 键 词：飞行人员 代谢综合征 受体 胰岛素 基因多态性 

分 类 号：R783.1[医药卫生—口腔医学]