根除幽门螺杆菌三联疗法联合化疗治疗晚期胃癌临床观察  

Clinical observation of tripal therapy for eradication of Helicobacter Pylori combined with chemotherapy on patients with HIP positive advanced gastric carcinoma.

作　　者：张小三[1] 赵曙[2] 杨晓煜[3] 马文杰[2] 张清媛[2] 

机构地区：[1]新乡医学院第一附属医院肿瘤科,卫辉453100 [2]哈尔滨医科大学附属肿瘤医院内三科 [3]新乡医学院病理教研室

出　　处：《实用肿瘤学杂志》2009年第6期528-530,540,共4页Practical Oncology Journal

摘　　要：目的比较克拉霉素、阿莫西林及奥美拉唑根除幽门螺杆菌三联疗法联合化疗治疗HP阳性晚期胃癌与常规化疗方案疗效及副反应差别。方法晚期幽门螺杆菌（HP）阳性胃癌患者42例，随机分为实验组与对照组，对照组患者采用奥沙利铂、5-氟脲嘧啶（5-Fu）联合亚叶酸钙方案化疗，每3周重复1次，6次为1个疗程，所有患者至少接受1个疗程的治疗。观察组在上述治疗方案的基础上用奥美拉唑、克拉霉素、阿莫西林口服。对两组疗效、毒副反应及患者生存期进行比较，观察两组治疗方法有效率及副反应情况的差别。结果治疗1个疗程后，观察组CR4例，PR9例，SD5例，PD4例，总有效率59．09％，而对照组分别为1例、5例、6例和8例，总有效率为30．0％，两组患者疗效比较差异具有统计学意义（P〈0．05）。两组患者毒副反应的发生情况差别无统计学意义。结论根除幽门螺杆菌三联疗法联合治疗HP阳性晚期胃癌与常规化疗方案相比有效率增高，副反应无明显差别，对晚期胃癌的治疗有一定临床意义。Objective To study the therapeutic effects of clarithromycin, amoxicillin and omeprazole tripal therapy for eradication of Helicobacter Pylori （ H. pylori ） combined with chemotherapy on patients with HP positive advanced gastric carcinoma. Methods 42 patients were all HP positive advanced gastric carcinoma who were divided into two groups. Patients in the control group were treated with FolFox regiment once three weeks. One course of treatment included 6 cycles. All patients were treated with one course at least. Patients in the treatment group were treated with Folfox regiment as well as omeprazole, clarithromycin and amoxicillin given orally. Observe the curative effect, toxic reaction and survival time of the two group after the treatment. Results The number of CR,PR,SD,PD was 4,9,5 and 4 respectively in the treatment group. The total effective rate was 59.09% ,while the corresponding number in the control group was 1,5,6,8 and 30.0%. The curative effect of the two group had statistical difference while the side and toxic effect of the two group was not different statistically. Conclusion Clarithromycin, amoxicillin and omoprazole tripal therapy for eradication of Helicobacter Pylori （H. pylori） combined with chemotherapy has higher effective rate,similar side -effect rate compared with the tra- ditional chemotherapy. It has certain significance in the treatment of advanced gastric carcinoma, though the two year survival rate was not obvious different in the two group.

关 键 词：胃癌 幽门螺杆菌 化疗 

分 类 号：R730.53[医药卫生—肿瘤]