HPV病毒负荷量与宫颈病变的关系  

The relation of HPV load and cervical lesions

作　　者：李雪梅[1] 李联昆[1] 高玉华[1] 龙再秋[1] 

机构地区：[1]辽宁省肿瘤医院妇科,沈阳110042

出　　处：《实用肿瘤学杂志》2009年第6期538-540,共3页Practical Oncology Journal

摘　　要：目的探讨高危型HPV病毒感染的负荷量与宫颈病变程度的相关性。方法对在我院官颈门诊就诊的2751例患者行HPV DNA检测，其中对971人行阴道镜下活检。结果不同级别的宫颈病变之间HPV负荷量检测值的分布没有明显的数值界限，但将病毒负荷分为低剂量组和高剂量组时宫颈病变程度与HPV负荷量显著相关（P〈0．01）。结论不同程度的宫颈病变之间病毒负荷量的检测值没有明显界限，病毒感染负荷不能代表病变的严重程度。但是病毒感染的负荷越高可以提示我们患宫颈高度病变的可能性越大。Object To discuss the relation of high risk HPV load and cervical lesions degree. Methods We tested HPV DNA of 2751 outpatients in our hospital, and performed biopsy to 971 patients with colposcope among them. Results There were not obvious difference among HPV load test value distribution of different degree cervical lesions. But there was remarkable relativity among the degrees of cervical lesions and HPV load, which was divided into low load dose and high load dose. Conclusion There are not distinct limit among virus load test value of different degree cervical lesions, and virus load can not represent the severity of cervical lesions. But the higher virus load can prompt the more possibility of high cervical lesions.

关 键 词：人乳头瘤病毒 病毒负荷 宫颈上皮内瘤样病变 

分 类 号：R737.33[医药卫生—肿瘤]