凋亡抑制因子livin和细胞周期蛋白D1在鼻内翻性乳头状瘤中的表达及意义  

Expression and sense of the apoptosis inhibitor livin and the cyclin D1 in nasal inverted papilloma

作　　者：王世军[1] 张丽琴 姚雅芬[1] 

机构地区：[1]黑龙江省佳木斯大学附属第一医院耳鼻喉科,黑龙江佳木斯154002 [2]黑龙江省鹤岗市人民医院耳鼻喉科,黑龙江鹤岗154100

出　　处：《中国现代医学杂志》2009年第18期2744-2746,2749,共4页China Journal of Modern Medicine

摘　　要：目的探讨凋亡抑制因子Livin和细胞周期蛋白D1(CyclinD1)在鼻内翻性乳头状瘤(NIP)中的表达及其在该病发生、发展中的意义。方法采用免疫组织化学方法检测38例鼻内翻性乳头状瘤、18例正常鼻腔黏膜(NM)、15例鼻鳞状细胞癌(NSCC)组织中Livin和CyclinD1的表达。结果Livin和CyclinD1在NM、NIP、NSCC中的表达呈递增趋势,两两对比,其差异均有极显著性(P<0.01)。NIP中Livin和CyclinD1的表达呈显著正相关(P<0.01)。结论凋亡抑制因子Livin和CyclinD1均参与NIP的发生、发展过程,并且两者之间存在反馈调节机制,在NIP的发生、发展过程中起协同作用。[ Objective ] To research the expression of the Apoptosis Inhibitor Livin and Cyclin D 1 in Nasal inverted papilloma （NIP） and their effect in the occurrence and development of NIP. [Methods] Detected the expres- sion of Livin and Cyclin D1 in tissue samples of 38 cases of NIP, 18 cases of normal nasal cavity mucosae （NM） and 15 cases of nasal prickle cell carcinoma （NSCC） using immunohistochemistry methods. [Results] The expression of Livin and Cyclin D1 in NM, NIP and NSCC had an increasing tendency and their differences were exceeding significant （P 〈0.01） contrasting each others. The expression of Livin and Cyclin D1 in NIP was notable positively correlated （P 〈0.01）. [ Conclusions] The result suggested that the Apoptosis Inhibitor Livin and Cyclin D1 both participated in genesia and growth of the NIP, there being a feedback regulation mechanism in them and they both joindy contributed to the formation of the NIP.

关 键 词：鼻内翻性乳头状瘤 凋亡抑制因子LIVIN 细胞周期蛋白D 免疫组织化学 

分 类 号：R739.62[医药卫生—肿瘤]