不同中医证型脓毒症内皮细胞功能的变化  

The Changes of in Septic Patients with Different TCM Syndromes

作　　者：杨敏春[1] 钱沈京[1] 张召才[1] 蔡国龙[1] 胡才宝[1] 许雅萍[1] 严静[1] 

机构地区：[1]浙江医院,浙江杭州310013

出　　处：《中华中医药学刊》2010年第1期128-130,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医名科"重症感染专科"建设项目(22);浙江省中医药管理局科研项目(2006C022;2007YB034)

摘　　要：目的:探讨脓毒症(Sepsis)内皮细胞功能的中医证型动态整体观察。方法:以26例对照组及经中医辩证的68例脓毒症住院患者(其中气分组23例,营分28例,血分组17例)为对象,分别采血,检测血栓调节蛋白soluble thrombomodulin(sTM)、E-选择素(E-selection,E-SLT)、内皮素-1(Endothelin-1,ET-1)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-2(IL-2)、白介素-4(IL-4)和白细胞计数(WBC)指标。结果:除IL-2外,所有参数值脓毒症组均显著高于对照组(P<0.05)。血分证的脓毒症sTM水平明显高于对照组、气分组(P<0.05)。结论:脓毒症sTM水平随着中医证型的变化而不同。动态观察sTM水平可作为脓毒症辨证的相关参考指标。Objective ：To study the changes and clinical significance of the in septic patients with different TCM syndromes. Methods： Blood samples were consecutively collected from 26 non - septic control patients and 68 septic patients. By TCM Syndrome Differentiation, the septic patients were divided into Qi -fen group （n = 23） , Yin -fen group （ n = 28 ） and Xue - fen group （ n = 17 ）. Serum soluble thrombomodulin （ sTM ）, E - selection （ E - SLT）, Endothelin （ ET - 1 ） , tumor necrosis factor （TNF） - ~t, interleukin （IL） - 6, 2, 4 and white blood cell （WBC） count were measured. Results ： In comparison with control, there was a significant difference in all the above parameters （ all P 〈 0.05 ） except for IL - 2 ; In septic patients, the Xue - Fen group has significantly increased sTM level compared to the control and Qi - fen group （ P 〈 0. 05 ）. Conclusion ： Serum sTM level altered in patients with different TCM Syndromes. Dynamic observation of serum sTM could contribute to the TCM Syndrome Differentiation for Sepsis.

关 键 词：脓毒血症 STM E-SLT ET-1 

分 类 号：R515.3[医药卫生—内科学]