2007-2008年北京地区25～54岁已婚妇女高危型人乳头状瘤病毒感染的流行病学调查  

Epidemiological study of high risk human papiUomavirus infection in 25 to 54 years old married women in Beijing

作　　者：武明辉[1] 张淞文[1] 张为远[2] 周保利[2] 谢争[1] 王建东[3] 冯静[1] 王军华[1] 蒋京伟[1] 朱力[4] 黄石全[1] 潘静[4] 刘新芝[4] 张运平[5] 赵温[5] 李虹[6] 罗晓航[6] 史坤翀[7] 王桂凤[7] 付立平[8] 李桂香[8] 陶惠芬 戴春香 何瑞霞 金蕾 刘广美 王奎香 叶家林[12] 刘似英 王梅 闫学明 胡桂玲 林如静 孙嫦月 曾红[15] 吴丽荣 程亚利 

机构地区：[1]首都医科大学附属北京妇产医院保健部,100026 [2]首都医科大学附属北京妇产医院产科,100026 [3]首都医科大学附属北京妇产医院肿瘤科,100026 [4]首都医科大学附属北京妇产医院病理科,100026 [5]北京市海淀区妇幼保健院保健部 [6]北京市朝阳区妇幼保健中心保健部 [7]北京市丰台区妇幼保健院保健部 [8]北京市怀柔区妇幼保健院妇保科 [9]北京市延庆县妇幼保健院保健部 [10]北京市通州区妇幼保健院妇保科 [11]北京市大兴区妇幼保健院妇保科 [12]北京市东城区妇幼保健院保健部 [13]北京市西城区妇幼保健所妇保科 [14]北京市石景山区妇幼保健院妇保科 [15]北京市崇文区妇幼保健院保健部 [16]北京市宣武区妇幼保健院保健部

出　　处：《中华妇产科杂志》2009年第12期892-897,共6页Chinese Journal of Obstetrics and Gynecology

基　　金：基金项目：北京市科技计划（D0906008040491）

摘　　要：目的了解北京地区妇女生殖道高危型人乳头状瘤病毒（HR—HPV）的感染状况及其分布特点，初步探讨HR—HPV感染的相关因素。方法于2007年3月至2008年9月，采用多阶段整群随机抽样的方法，在北京地区抽取12个区县137个社区25～54岁已婚妇女6185例进行妇科检佥、宫颈HR—HPV检测及细胞学检查，并进行问卷调查。应用EpiData3．0软件双次录入、审核数据后，应用SPSS15．0软件进行统计学分析。结果（1）北京地区25～54岁已婚妇女生殖道HR—HPV感染率为9．89％。城区、近郊、远郊妇女的HR—HPV感染率分别为9．34％、10．51％和9．51％（P〉0．05）；本市、外地户籍妇女的HR—HPV感染率分别为9．53％和11．30％（P〈0．05）。（2）HR—HPV感染的年龄分布特点：25～44岁年龄段妇女的HR—HPV感染率稳定在10％左右，30～34岁者HR—HPV感染率最高，为11．21％；44岁以上则随着年龄增长感染率逐渐下降，50-54岁降至最低（7．78％）。（3）多元logistic回归分析显爪，家庭人均月收入≥1000元、配偶性伴侣数〉1个者、外地户籍、文化程度为高中及以上者，其感染HR—HPV的可能性大。（4）感染HR—HPV人群的宫颈上皮内瘤变（CIN）患病率明显高于未感染人群（分别为29．76％、3．32％，P〈0．01）。结论（1）北京地区25～54岁已婚妇女牛殖道HR—HPV感染率为9．9％，在地域分布上无差异。（2）北京地区HR—HPV感染的危险人群为家庭经济条件优越者、配偶多个性伴侣者、外地户籍及文化程度较高者。（3）HR—HPV感染是发生CIN及宫颈癌的重要因素，但HR—HPV感染并不等于一定发生CIN和宫颈癌；应对HR—HPV感染者定期随访以了解其感染及宫颈的动态变化。Objective To investigate high risk human papillomavirus （HR-HPV） prevalence among married women in Beijing and to study the high risk factors. Methods During March 2007 to September 2008, a total of 6185 married women sampled from 137 communities in 12 districts were screened by HR-HPV DNA test and cytological test. The interview was carried out with unified questionnaires. The database was set up and twice entered in EpiData 3.0. After checked up, the data were analyzed in SPSS 15.0. Results （ 1 ） The HR-HPV infection rate was 9. 89%. The HR-HPV infection rate of the city zone, the suburb and the exurb were 9. 34% , 10. 51% and 9. 51% （P 〉0. 05）. The HR-HPV infection rate of the native and the outlander were 9. 53% , 11.30% （ P 〈 0. 05）. （2） The age distribution of HR-HPV infection was that the rate was around 10% among 25 to 44 age groups, which was the highest （ 11. ：21% ） in 30 to 34 age group; then the rate was descended as the age raising, the rate of 50 to 54 age group was the lowest （7.78%）. （3） Multiple logistic regression showed that the related risk factors of HR-HPV infection mainly included 1000 RMB and above of family income per person per month, possessing more than 1 sexual partner of her husband, outlander and high levels of education. （4） The prevalence of cervical intraepithelial neoplasia （CIN） in HR-HPV positive group was significantly higher than that in HR-HPV negative group （29.76% vs 3.32%, P〈0. 01）. Conclusions （1） The HR-HPV infection rate among aged 25 to 54 years was 9.9% and there was no significant difference in area distribution. （2） The high risk population which should strengthen screening was the married bearing-age women with high level of family income, outlander, high levels of education and her husband possessing more than 1 sexual partner. （3） HR-HPV infection is the main risk factor for CIN and cervical cancer, while does not provide a causal relationship with them. The high risk population should be checked r

关 键 词：乳头状瘤病毒 人 乳头状瘤病毒感染 子宫颈 抽样研究 问卷调查 流行病学 

分 类 号：R737.33[医药卫生—肿瘤]