CT引导下^(125)I粒子植入治疗鼻咽癌放疗后残留病灶的疗效  

Effect of CT-guided implantation of radioactive ^(125)I seeds on the residual foci of nasopharyngeal carcinoma after radiotherapy

作　　者：谢岳云[1] 伍靖武[1] 王鸿智[1] 田秀荣[1] 鲍忠平[1] 

机构地区：[1]解放军181医院肿瘤治疗中心,桂林541002

出　　处：《肿瘤》2009年第12期1170-1172,共3页Tumor

摘　　要：目的:评价CT引导下125I粒子植入治疗鼻咽癌放疗后残留肿瘤病灶的疗效。方法:2007年1月—2008年1月本院25例放疗后有残留肿瘤病灶的鼻咽癌患者接受了125I粒子植入治疗。采用三维治疗计划系统(treatment planning system,TPS)计算植入125I粒子数量和总剂量。CT引导下将125I放射性粒子植入残留肿瘤病灶中,并对植入的125I放射性粒子剂量分布进行验证。术后3、6和12个月定期进行鼻咽内窥镜和CT检查,并评价近期疗效和不良反应。结果:术后12个月时,25例患者中完全缓解20例、部分缓解2例、无变化2例、疾病进展1例,总有效率(完全缓解+部分缓解)为88.0%。所有患者于术中和术后均未发生严重并发症。结论:CT引导下125I粒子植入治疗鼻咽癌放疗后残留肿瘤病灶是一种安全而有效的治疗方法。Objective：To evaluate the efficacy of computed tomography（CT）-guided implantation of radioactive 125I seeds in the treatment of residual foci of nasopharyngeal carcinoma after radiotherapy.Methods：Twenty-five nasopharyngeal carcinoma patients who had residual foci after radiotherapy were implanted radioactive 125I seeds from January 2007 to January 2008 in our hospital.Three-dimensional treatment planning system（TPS） was used to calculate the quantity and total dosage of 125I seeds.The radioactive 125I seeds were implanted into residual foci under CT guidance.The dosage distribution of radioactive 125I seeds were verified after surgery.The nasopharyngeal endoscopy CT scans were performed at 3,6,and 12 months after surgery and the short-term efficacy and adverse reaction were evaluated.Results：Out of the 25 patients,20 patients had complete response（CR）,2 patients had partial response（PR）,2 patients had no change（NC）,and 1 patient had progressive diseases（PD）.The overall effective rate（CR＋PR） was 88.0%.All patients had no serious postoperative complications.Conclusion：CT-guided implantation of radioactive 125I seed was an effective and safe method in the treatment of the residual foci of nasopharyngeal carcinoma after radiotherapy.

关 键 词：鼻咽肿瘤 近距离放射疗法 肿瘤 残余 碘-125 

分 类 号：R739.6[医药卫生—肿瘤]