化疗对乳腺癌患者性激素及月经的影响  

Effect of postoperative adjuvant chemotherapy on sex homones and menstruation

作　　者：李洪涛[1] 周遵艳[1] 戴丹菁[1] 张文涛[1] 喻世华[1] 陶劲松[1] 杨继元[1] 

机构地区：[1]荆州市第一人民医院肿瘤科,湖北荆州434000

出　　处：《现代肿瘤医学》2010年第1期76-77,共2页Journal of Modern Oncology

摘　　要：目的:研究术后辅助化疗对乳腺癌患者性激素的影响及与月经的关系。方法:对60例乳腺癌患者术后行6个周期的CAF方案辅助化疗,观察化疗期间患者月经和血浆雌二醇(E2)、孕酮(P)、黄体生成素(LH)、促卵泡素(FSH)的变化及其影响因素。结果:40例患者化疗期间发生闭经(闭经组),20例化疗结束时仍有月经(未闭经组)。其中闭经组8例化疗后可恢复,32例不可恢复。闭经组患者血浆E2、P水平下降(P<0.05)。闭经发生率与年龄、化疗药物强度和化疗进程呈正相关(P<0.05),其中黄体生成素(LH)、促卵泡素(FSH)下降组月经不可再恢复。结论:化疗可抑制乳腺癌患者性激素的分泌,导致闭经的发生。Objective：To study the effect of postoperative adjuvant chemotherapy on sex hormones and menstruation in the patients of breat cancer. Methods： Sixty two cases of breast cancer received adjuvant CAF chemotherapy postoperatively. During chemotherapy period,the changes of menstruation and plasma levels of estradiol （E2） , progesterone （P） LH, FSH ,were observed. Results：Forty cases developed amenorrhea during the chemotherapy period （amenorrheic group） , however,20 cases continued to have menstrual cycle （nonamenorrheic group）. Among the amenorrheic patients 8 cases recovered menorrhea. Plasma level of E2 and P in amenorrheric group declined, singnificantly in amenorrhic group comparred with nonamenorrhic group. The frequency of amenorrhea correlated with the age, chemotherapy drugs and duwration of chemotherapy. The plasma levels of LH and FSH were decreased in amenorrhic patents without recovery. Conclusion：Chemotherapy suppresses the ovarian function of sex hormenes in patients with breast cancer patients, which may lead to amenorrhea.

关 键 词：乳腺癌 化疗 月经 性激素 

分 类 号：R730.53[医药卫生—肿瘤]