TECIA法体外放射敏感性实验对原发性肺鳞癌放疗个体化方案选择的意义  

Radiosensitivity test with TECIA for primary lung cancer in vitro and the choice of individualized radiotherapy

作　　者：齐宇红[1] 尹永信[1] 邵秋菊[1] 梁军[1] 张金山[2] 李臻[2] 严长有 

机构地区：[1]第四军医大学唐都医院放疗科,陕西西安710038 [2]第四军医大学组织与胚胎学教研室,陕西西安710032 [3]南京先声药业有限公司,江苏南京210042

出　　处：《现代肿瘤医学》2010年第1期87-89,共3页Journal of Modern Oncology

摘　　要：目的:建立人原发性肺鳞癌的组织培养放疗敏感性检测法,快速确定人原发性肺鳞癌组织的辐射敏感性的个体差异,用于筛选放疗方案及指导临床肿瘤个体化放疗方案。方法:采用TECIA法检测不同个体原发性肺鳞癌组织在不同剂量、不同分次放疗方案照射后不同时间的细胞凋亡水平。比较不同剂量、不同分次放疗方案照射后不同时间的细胞凋亡水平的差异。结果:TECIA法发现,照射前人原发性肺鳞癌组织细胞凋亡指数较低,放疗后出现较高的细胞凋亡指数,与放疗剂量呈正相关。结论:肿瘤放射敏感性实验对指导患者的个体化治疗具有重要的价值。Objective： To evaluate the effect of radiosensitivity test in vitro for primary lung cancer in clinical individual radiotherapy. Methods ：The radiosensitivity of six spicimens of lung cancer was determined by TECIA method in vitro. The radiotherapy group tested for lung cancer were divided into control,2Gy × 9f,4Gy × 9f,6Gy × 7f,8Gy × 5 f, 10Gy × 3 f, 20Gy × 1 f, 30Gy × 1 f groups. Results： There was significant difference in the radiosensitivity between each group. Among all, primary lung cancer was most sensitive to 30Gy. Conclusion：In vitro radiosensitivity test of TECIA assay may has guidance value for individual radiotherapy of primary lung cancer.

关 键 词：肺癌 TECIA 放射敏感性 个体化放疗 

分 类 号：R730.55[医药卫生—肿瘤]