缺氧诱导因子-1及其靶基因在肿瘤恶性进展中的作用  

Effect of hypoxia-inducible factor-1 (HIF-1) and target genes on malignant tumor progression

作　　者：赵静[1] 师永红[1] 

机构地区：[1]内蒙古医学院病理学中心,附属医院病理科,内蒙古呼和浩特010059

出　　处：《现代肿瘤医学》2010年第1期166-168,共3页Journal of Modern Oncology

基　　金：国家自然科学基金项目(30560057;30860331)

摘　　要：缺血缺氧的微环境是肿瘤形成和演进过程中普遍存在的现象。在缺氧条件下,肿瘤细胞改变代谢特点以保证存活并不断生长。缺氧诱导因子-1(HIF-1)作为缺氧状态下细胞内重要的转录激活因子,可直接或间接调节100多个靶基因的转录激活,表达靶蛋白,使得肿瘤细胞能适应缺氧微环境,并且保持不断增殖、浸润和转移的能力。Hypoxic or ischemic microenvironment is a common phenomena in tumor growth and progression. Under hypoxic condition,tumor cells change its metabolic character to keep survive and growth. Hypoxia - inducible factor - 1 （ HIF - 1 ） as the most important transcription activator under the hypoxic condition , it regulates transcription activation of more than 100 target genes directly or indirectly, which help tumor cells adapt to hypoxic environment, and keep the ability of proliferation, infiltration and metastasis.

关 键 词：缺氧诱导因子-1 靶基因 肿瘤 

分 类 号：R730.231[医药卫生—肿瘤]