老年恶性肿瘤患者凝血-纤溶功能变化的临床观察  

作　　者：宫雅南[1] 董莲萍[1] 周慧群[1] 

机构地区：[1]广东广州医学院第二附属医院老年病科,510260

出　　处：《当代医学》2010年第1期118-119,共2页Contemporary Medicine

摘　　要：目的从凝血-纤溶功能变化探讨老年肿瘤患者血栓形成的机制及其临床意义。方法将32例老年肿瘤患者和20例良性疾病患者分为肿瘤组和非肿瘤,20例正常人作为对照组,测定血浆中vWF:Ag,FⅧ:C、AT-Ⅲ、D-Dimer的水平。结果老年肿瘤患者的vWF:Ag、FⅧ:C、D-Dimer水平比非肿瘤患者和正常人明显增高(P<0.01),AT-Ⅲ水平比非肿瘤患者和正常人降低(P<0.05);深静脉血栓形成发生率为21.87%。结论老年肿瘤患者机体处于高凝状态,深静脉血栓形成的发生率比非肿瘤者高。Objective to evaluate pathogenesis of thrombosis and its clinic values from changes of coagulation and fibrinolysis in elderly tumor patients. Methods vWF：Ag, FⅧ：C, AT-III and D-Dimer protein levels in blood plasm were quantifi.ed in the tumor group of 32 elderly tumor patients, the non-tumor group of 20 patients suffering from benign diseases and the control group of 20 health adults. Results v WF：Ag,FⅧ：C and D-Dimer protein levels were considerably increased in the tumor group compared to the non-tumor group and the control group （P〈0.01 ）. Conversely, AT- III protein level in the tumor group was significantly lower than that in the other two groups （P〈0.05）. Incidence rate of deep vein thrombosis was observed about 21.87% in the tumor group. Conclusion elderly tumor patients suffer from the hypercoagulabale state, resulting in a higher incidence rate of deep vein thrombosis than non-tumor patients.

关 键 词：恶性肿瘤 血栓形成 凝血-纤溶 老年人 患者 临床 

分 类 号：R730.4[医药卫生—肿瘤]