神经生长因子对脑梗死大鼠的神经保护作用  

Neuroprotective Effects of Nerve Growth Factor on Expremiental Cerebral Infarction Rat

作　　者：张燕平[1] 

机构地区：[1]河南中医学院第一附属医院神经内科,河南郑州450000

出　　处：《中国现代医生》2010年第1期7-8,共2页China Modern Doctor

摘　　要：目的观察鼠神经生长因子(nerve growth factor,NGF)对脑缺血大鼠的神经保护作用。方法建立MCAO大鼠模型,研究NGF对脑缺血大鼠脑梗死体积和行为学评分的影响。结果NGF能够减少MCAO大鼠脑梗死体积和行为学评分(P<0.05)。结论NGF可以明显减小脑梗死体积,其对脑梗死大鼠具有明显的神经保护作用。Objective To evaluate the neuroprotective effects of nerve growth factor（NGF） on cerebral ischemia in rats. Methods A rat model of cerebral ischemia reperfusion injury was established by the middle cerebral artery embolization（MCAO ）. The infarct volume and behavioral score were recorded to evaluate the protective effect of progesterone on cerebral isehemia reperfusion injury. Results The administration of NGF significantly reduced infarct volume, and improved behavioral outcomes in MCAO rats. Conclusion NGF plays a neurooprotective role in cerebral ischemia in rats.

关 键 词：神经生长因子 脑梗死 大鼠 保护作用 

分 类 号：R743[医药卫生—神经病学与精神病学]