胸腺在免疫毒性病理学评价中的作用和意义  

Role and significance of thymus in pathological evaluation of immunotoxicity

作　　者：林志[1] 李珊珊[1] 张頔[1] 李波[1] 杨艳伟[1] 

机构地区：[1]中国药品生物制品检定所国家药物安全评价监测中心,北京100176

出　　处：《中国新药杂志》2009年第24期2309-2312,共4页Chinese Journal of New Drugs

基　　金：国家科技支撑计划(2006BAI14B06)

摘　　要：胸腺是中枢性淋巴器官,无须抗原的刺激T淋巴细胞在皮质自主地进行分化和成熟,这是免疫系统正常功能发育的重要组成部分。当暴露于免疫毒性物质和内源性糖皮质激素时,胸腺是敏感的靶器官,胸腺的大小或重量出现明显的降低,这往往是化合物或药物导致的敏感的皮质胸腺细胞改变最初观测到的指标。因此,胸腺组织病理学和重量的改变与免疫毒性的筛选具有特定的关联,对胸腺的病理学评价在免疫毒性研究中具有重要作用和意义。文中从胸腺生理和毒性病理学的角度对其作用和研究意义进行综述。The thymus is a central lymphoid organ. T lymphocytes undergo differentiation and maturation autonomously in thymus cortex without the need for antigenic stimulation. This is essential for the normal development and function of the immune system. The thymus has been shown to be a sensitive target organ following expo- sure to immunotoxicants and endogenous corticosteroids. A decrease in size or weight of thymus is often one of the first noted measures of test chemical-induced effects. The cortical thymic lymphocytes are especially susceptible. Therefore,changes in thymus histopathology and weight are considered to be of particular relevance for immunotoxicity screening,and the pathological evaluation of thymus plays an important role in immunotoxicity study.

关 键 词：免疫毒性 病理学 胸腺 

分 类 号：R975.3[医药卫生—药品]