中国药品不良反应成因分析及预防措施  

Adverse drug reactions in China:causes analysis and prevention measures

作　　者：金丹[1] 董铎[2] 魏晶[1] 田春华[2] 杨月明[1] 王嘉仡[1] 杜晓曦[2] 

机构地区：[1]辽宁省药品不良反应监测中心,沈阳110003 [2]国家药品不良反应监测中心,北京100045

出　　处：《中国新药杂志》2009年第24期2376-2381,共6页Chinese Journal of New Drugs

基　　金：国家科技支撑计划课题(2006BAIl4B04)

摘　　要：目的:探讨和分析我国药品不良反应发生的各种因素,为减少和避免药品不良反应的发生提供参考。方法:分析2006年我国严重药品不良反应数据并辅以相关文献,对8128例严重病例从涉及的药品、不良反应临床表现等方面进行回顾性分析,并对我国药品不良反应的成因进行分析归纳。结果:2006年我国严重药品不良反应报告涉及的药品以抗微生物药物为多,不良反应累及的系统-器官以全身性损害为多。药品不良反应的成因复杂,与药物因素、机体因素、不合理用药等相关。结论:应加强药品研究、生产、流通、使用、监管等各环节工作,预防和减少药品不良反应的发生。Objective：To analyze the causes of adverse drug reactions （ADR） in China, and to provide references for administration and ensure the safety of drug use. Methods：We analyzed the serious ADR reports in 2006 ,and reviewed the relevant literature. The causes were evaluated and summarized based on analysis of related drugs and clinical manifestation in 8 128 cases. Results：The majority of the reported serious ADR in 2006 was induced by antimicrobial drugs. ADR mainly included systemic damage. The causes of ADR were complicated, in- cluding drug factors, patient factors and current situations of unreasonable administration. Conclusion： In aspects of drug research, manufacture, distribution and use, administration should be further strengthened, so as to ensure the safety of medication.

关 键 词：药品不良反应 成因 预防 

分 类 号：R969.3[医药卫生—药理学]