Nogo-NgR在中枢神经系统发育中的作用  

Roles of Nogo-NgR in developing of central nervous system

作　　者：霍妍[1] 袁容娣[1] 叶剑[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所眼科,重庆市400042

出　　处：《眼科新进展》2010年第1期88-90,共3页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:30572009)~~

摘　　要：成年哺乳动物中枢神经系统损伤后神经元轴突的再生能力极为有限,其中抑制性因素起重要作用,Nogo基因是近些年来发现的新的轴突再生抑制因子。然而,Nogo-NgR信号通路在神经发育中的功能尚不明确,其在轴突损伤再生过程中可能还起着抑制之外的作用。本文就Nogo-NgR在中枢神经系统发育中作用的研究进展进行综述。Central nervous system may not regenerate after injury in the adult mammalian.Axonal regeneration is believed to be prevented by multiple factors and myelin-derived inhibitor have been proposed to be an important factor.Nogo is one kind of myelin-derived inhibitor.However,the function of Nogo-NgR signaling pathway in neural development is unclear.Nogo-NgR system may not only inhibit neuronal regeneration but also take part in the neuronal development.This article mainly reviews the roles of Nogo-NgR in developing of central nervous system.

关 键 词：NOGO NGR 中枢神经系统 发育 

分 类 号：R774[医药卫生—眼科]