美金刚联合尼莫地平治疗老年性痴呆的疗效及安全性  

Effect of Memantine Combined with Nimodipine on Senile Dementia and Its Safety

作　　者：刘艳[1] 赵晓玲[1] 王蕾[1] 高励[1] 郝玉曼[1] 沈富伟[1] 张海涛[1] 何柳[1] 

机构地区：[1]四川省成都市第三人民医院神经内科,610031

出　　处：《中国全科医学》2010年第2期135-136,141,共3页Chinese General Practice

基　　金：四川省卫生厅科学研究项目(20080044)

摘　　要：目的探讨美金刚联合尼莫地平对老年性痴呆患者认知功能和行为能力的改善作用及安全性。方法将78例老年性痴呆患者随机分为3个组,在治疗前和治疗12周后进行简易精神状态量表(MMSE)、日常生活活动能力量表(ADL)和临床痴呆评定量表(CDR)的评分并比较3组的评分结果。结果单用美金刚治疗组治疗后MMSE评分为(19.0±4.9)分,ADL评分为(30.3±11.3)分,较对照组〔分别为(16.8±4.8)分和(33.7±12.0)分〕有显著改善,差异有统计学意义(P<0.05);联合用药组MMSE评分为(20.8±4.0)分,ADL评分为(27.2±10.7)分,与单用美金刚治疗组比较,差异亦均有统计学意义(P<0.05)。结论美金刚能有效改善老年性痴呆患者的认知功能及日常生活能力,与尼莫地平联合治疗的效果优于单独使用,且安全性较高。Objective To explore the role of memantine combined with nimodipine in improving cognitive function and behavioral capacity in senile dementia （SD） patients and its safety. Methods Seventy - eight SD patients were divided random- ly into 3 groups. MMSE, ADL and CDR scores were assessed before treatement and after 12 weeks of treatment. The results were compared between 3 groups. Results MMSE and ADL scores of memantine group （ 19.0± 4. 9, 30. 3± 11.3, respectively） improved significantly when compared with control （ 19.0 ±4. 9, 33.7 ± 12. 0, respectively）, and the difference was significant （P 〈 0. 05 ）. There was significant difference in MMSE and ADL scores between groups combined treatment （20. 8± 4. 0, 27. 2 ＋10.7, respectively） and memantine （P 〈 0. 05 ）. Conclusion Memantine can improve effectively the cognitive function and daily living skills. Its combination with nimodipine is superior to its single use with a higher safety.

关 键 词：美金刚 尼莫地平 阿尔茨海默病 痴呆 血管性 

分 类 号：R749.16[医药卫生—神经病学与精神病学]