VEGF与中枢神经系统疾病的关系  

VEGF and central nervous system diseases

作　　者：章露易[1] 范彦英[1] 陈忠[1] 

机构地区：[1]浙江大学医学院,浙江杭州310058

出　　处：《浙江大学学报（医学版）》2009年第6期644-648,共5页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金(30600757;30801392);博士后科学基金(20070420236)

摘　　要：VEGF是一种由缺氧诱导的血管生长相关肽,在脑内有比较丰富的表达。VEGF具有神经营养、神经保护、抗凋亡、细胞增殖、提高毛细血管渗透压等广泛的生物学作用。近年来的研究发现,VEGF与多种中枢神经系统疾病相关,如脑缺血性疾病、阿尔茨海默病、帕金森病等。深入研究VEGF与中枢神经系统疾病的内在关系,研究和开发相关药物,将成为中枢神经系统疾病治疗的热点和新思路。Vascular endothelial growth factor （VEGF or VEGF-A） is a hypoxia induced angiogenic growth factor that is potent in neurotrophy, neuroprotection, anti-apoptosis and cell proliferation. Recent reports suggest that VEGF is related to many central nervous system diseases,such as cerebral ischemic disease,Alzheimer＇s disease and Parkinson＇s disease. Further study of the relationship between VEGF and central nervous system diseases,and investigation of VEGF related drugs will shed light on a new way for treatment of central nervous system diseases.

关 键 词：血管内皮生长因子类 VEGF 脑缺血 阿尔茨海默病 帕金森病 

分 类 号：R741[医药卫生—神经病学与精神病学]