慢血流现象与内皮功能的相关分析  

Relationship between slow coronary flow and endothelial disorder

作　　者：韩雅君[1] 卢微[1] 王玲[1] 田志强[1] 董淑敏[1] 

机构地区：[1]内蒙古自治区医院心内科,呼和浩特市010017

出　　处：《中国介入心脏病学杂志》2009年第6期332-334,共3页Chinese Journal of Interventional Cardiology

基　　金：内蒙古自治区自然科学基金项目(200711020925)

摘　　要：目的进一步探讨慢血流现象与内皮功能紊乱的相关性。方法112例冠状动脉造影正常患者,用TIMI帧数方法进行慢血流和正常血流分组。对慢血流和正常血流患者性别、年龄、胆固醇、高血压、糖尿病、吸烟、内皮素(ET)-1、一氧化氮(NO)、白介素(IL)-6等因素对比分析。结果慢血流组男性多于女性(30例比6例),吸烟患者多于不吸烟者(22例比14例)。慢血流组ET-1和IL-6水平高于正常血流组(分别为108.42±36.12pg/mL比84.74±39.16pg/mL和158.28±178.86pg/mL比108.07±84.43pg/mL,P均<0.05);慢血流组NO水平低于正常血流组(35.66±12.28μmol/L比42.74±17.51μmol/L,P<0.05)。结论慢血流现象与内皮功能紊乱相关。评价慢血流现象时要考虑影响血流的其他因素。Objective To study the relationship between slow coronary flow and endothelium disorder. Methods One hundred and twelve patients with normal coronary angiography were divided into the slow flow group （n =38） and the normal flow group （n =84） in terms of their TIMI frame counts. Risk factors including sex, age, cholesterol, hypertension, diabetes, history of smoking and blood levels of endothelium-1, nitric oxide and interleukin-6 were compared between the 2 groups. Results Slow coronary flow was more common in male than in female （45 vs 39）. Patients who smoked showed a higher incidence of slow eoroany flow than non-smoker patients （ P = 0. 010）. The blood levels of ET-1 （ 108.42 ± 0. 81 pg/mL vs84.74 ±39.16 pg/mL, P =0.001） and IL-6 （158.28 ± 178.86 pg/mL vs 108.07 ±84.43 pg/mL,P =0. 019） was higher in the slow flow group but with a lower levels of NO （35.66 ± 12. 28 μmol/l, vs 42. 74 ± 17.51 μmol/L, P = 0. 032 ） when compare with the nomal coronary folw group. Conclusion Slow coronary flow is related to endothelium disorder but other risk factors should also be taken into consideration.

关 键 词：冠状血管 血流速度 内皮 

分 类 号：R364.12[医药卫生—病理学] R542.22[医药卫生—基础医学]