内含子miRNA反馈调节宿主基因的表达与功能研究进展  

Advances in research on intronic miRNAs feedback regulation of their host genes

作　　者：黄宝春[1] 曹国军[1] 邵宁生[1] 

机构地区：[1]军事医学科学院基础医学研究所,北京100850

出　　处：《军事医学科学院院刊》2009年第6期580-582,595,共4页Bulletin of the Academy of Military Medical Sciences

基　　金：国家重点基础研究发展规划(2005CB724600);国家自然基金面上项目(30600110)资助项目

摘　　要：miRNA是近年来发现的一类重要的基因表达调控因子。研究发现,许多miRNA位于编码蛋白基因(宿主基因)的内含子中,称为内含子miRNA。现有的证据表明,大多数内含子miRNA和它们的宿主基因表达一致,提示这些内含子miRNA参与宿主基因在功能和表达上的调控,本文就这方面的最新研究进展做一综述。miRNAs were discovered less than a decade ago,and have emerged as important regulators of gene expression in mammals.A large number of miRNAs have been identified to be located within the intronic regions of protein-encoding genes（host genes） and called intronic miRNAs.The intronic miRNAs may play a key role in regulating the expression and function of their host genes due to the fact that most of them are co-expressed with the host genes.In this paper,the recent advances on the research on potential relationship between intronic miRNAs and their host genes are reviewed.

关 键 词：MIRNA 内含子 宿主基因 反馈调节 

分 类 号：Q75[生物学—分子生物学]