中国汉族炎症性肠病幽门螺杆菌感染状况分析  

Low prevalence of Helicobacter pylori infection in Chinese Han patients with inflammatory bowel disease

作　　者：庞智[1,2] 李美芬[3] 皇甫照[2] 周春立[1] 沈必武[1] 

机构地区：[1]江苏省苏州市立医院北区消化内科,江苏省苏州市215008 [2]苏州市消化系疾病与营养研究中心,江苏省苏州市215008 [3]苏州市立医院北区检验科,江苏省苏州市215008

出　　处：《世界华人消化杂志》2009年第35期3661-3665,共5页World Chinese Journal of Digestology

摘　　要：目的:调查中国汉族IBD患者Hpylori感染情况和IBD治疗药物及克罗恩病(CD)表型与Hpylori感染的可能关系.方法:收集106例IBD患者,其中包括54例溃疡性结肠炎(UC)和52例CD,对照组包括106例年龄和性别及社会经济状况与之匹配且接受了常规的体格检查的健康人.采用HpyloriIgG抗体胶体金免疫层析快速诊断试验比较了IBD患者和健康对照者Hpylori的感染率.结果:IBD患者和对照组以及UC和CD患者之间Hpylori感染率,均具有显著性差异(31.1% vs 61.3%,P<0.01;37.0% vs 25.0%,P<0.05).在IBD患者中,曾服用甲硝唑(22.3%)或喹诺酮类抗菌药(19.1%)的患者比对照组H pylori感染率显著降低,而没有服用抗生素的患者也表明H pylori感染率显著低于对照组.IBD患者的表型特征与H pylori感染率没有显著的关系(P>0.05).结论:中国汉族IBD患者,特别是CD患者的Hpylori感染率显著的低于正常对照者,认为H pylori感染在IBD患者中可能是一种低危险因素.AIM： To investigate the prevalence of Helicobacter pylori （H pylori） infection in Chinese Han patients with inflammatory bowel disease （IBD） and analyze possible associations between H pylori infection and drug therapy for IBD as well as between H pylori infection and the phenotypes of Crohn＇s disease （CD）. METHODS： One hundred and six unselected patients with IBD, including 54 ulcerative colitis （UC） patients and 52 CD patients, and 106 ageand gender-matched healthy individuals who received a comprehensive medical examination for a regular checkup purpose were included in the study. The rates of H pylori infection as detected by the gold immunochromatographic assay （GICA） for serum anti-H pylori IgG antibody were compared between IBD patients and controls. RESULTS： A statistically significant difference was noted in H pylori infection rate between IBD patients （31.1%） and controls （61.3%）, and between UC patients （37.0%） and CD patients （25.0%）. IBD patients with a history of taking metronidazole （22.3%） or quinolones （19.1%） were found to have a meaningfully lower infection rate, but those who did not take antibiotics still had a significantly lower H pylori infection rate than controls （P 〈 0.01）. No significant correlation was noted between the phenotypic characteristics and H pylori infection rate in CD patients. CONCLUSION： Chinese Hart patients with IBD, particularly CD, have a significantly lower H pylori infection rate than healthy controls, suggesting that H pylori infection may predict a low risk of IBD in adults.

关 键 词：幽门螺杆菌 溃疡性结肠炎 克罗恩病 

分 类 号：R574[医药卫生—消化系统]