243例结直肠癌患者预后因素分析  

Analysis of prognostic factors in 243 colorectal cancer patients

作　　者：张洋[1] 丁彦青[1] 李建明[1] 

机构地区：[1]南方医科大学南方医院病理科,南方医科大学基础医学院病理学系,广东省分子肿瘤病理重点实验室,教育部广东省共建人类重大疾病转录组学和蛋白组学重点实验室,广东广州510515

出　　处：《中国热带医学》2010年第1期102-103,106,共3页China Tropical Medicine

基　　金：国家自然科学基金资助课题(批准号:30500241;30670968和30700286)

摘　　要：目的目前结直肠癌发病率逐年上升,已经成为危害我国人民健康的常见原因之一。本研究旨在探讨结直肠癌患者临床病理特征及其与预后的关系。方法收集南方医科大学南方医院普通外科2005年1月～2008年9月期间结直肠癌患者情况,进行随访。选择年龄、性别、肿瘤大小、肿瘤大体类型、组织类型、肠壁浸润深度、Dukes分期、是否存在淋巴结转移等8项临床病理指标,用单因素和多因素分析的方法研究其对243例结直肠癌患者预后的影响。结果单因素分析结果显示,年龄、Dukes’分期、是否存在淋巴结转移为影响结直肠癌患者预后的因素。COX比例危险回归模型多因素分析显示,仅年龄及是否存在淋巴结转移结直肠癌患者预后的独立影响因素。结论年龄和是否存在淋巴结转移是结直肠癌患者预后的重要指标。Objective To investigate the clinical features and prognostic factors in 243 eoloreetal cancer cases. Methods The clinicopathologie irLformations about age,sex and size,gross findings,histological types,infdtrative conditions, Dukes~ stage and lymph node metastasis of the tumor in 243 eolorectal cancer cases were collected and analyzed by univariate and multivariate analysis. Results Univariate analysis revealed that age,Dukest stage and lymph node metastasis were prognostic factors of patients with coloreetal cancer. Multivariate analysis of COX model indicated that age and lymph node metastasis were two independent prognostic factors. Conclusion Age and lymph node metastasis were two independent prognostic factors of colorectal cancer.

关 键 词：结直肠肿瘤 预后 多因素分析 

分 类 号：R735.35[医药卫生—肿瘤]