幽门螺杆菌感染和其他生活因素与胃癌关系研究  

Relation among helicobacter pylori infection,living factors and gastric carcinoma

作　　者：吴炎 张万岱[1,2] 杨海涛 吴鸿悌[1,2] 

机构地区：[1]蚌埠医学院附属医院消化科 [2]第一军医大学南方医院消化科

出　　处：《蚌埠医学院学报》1998年第5期351-352,共2页Journal of Bengbu Medical College

摘　　要：目的：探讨幽门螺杆菌（ＨＰ）感染和其他生活因素与胃癌的关系。方法：胃镜及病理证实的胃癌７３例，其他肿瘤患者７３例，进行１∶１病例对照研究，采用间接ＥＬＩＳＡ法检测血清抗ＨＰＩｇＧ抗体水平。结果：胃癌组ＨＰ感染率为５８．９％，平均抗体水平为２．２９±０．８５，显著高于对照组的感染率４２．５％（Ｐ＜０．０５）和平均抗体水平１．８４±０．６５（Ｐ＜０．００１）。胃癌组与对照组相比，比值比（ＯＲ）值呈线性趋势（Ｐ＝０．００５）。结论：ＨＰ感染、某些生活因素与胃癌有关，胃癌的危险性随抗ＨＰＩｇＧ抗体滴度的升高而升高。Objective:To investigate the relation among helicobacter pylori(HP) infection,living factors and gastric carcinoma.Methods:73 cases of gastric carcinoma(male:female ratio 2.04∶1,mean age 56.0),with 73 cases of other tumors(male:famale ratio 1.70∶1,mean age 55.6) as 1∶1 case matched control were examined with indirect ELISA for detection of HP IgG antibody in serum.Results:The positive rate of HP infection and mean level of HP IgG antibody were 58.9% and 2.29±0.85 in gastric cancer group,which were significantly higher than those of the control group(42.5% and 1.84±0.65, P <0.05,and P <0.001).The odds ratio (OR) of gastric carcinoma group was in linear tendency in comparing to control group ( P =0.005).Conclusions:Infection with HP and some living factors are associated with gastric carcinoma.The risk of gastric carcinoma increases as the level of HP IgG antibody is increasing.

关 键 词：胃肿瘤 幽门螺杆菌 回归分析 

分 类 号：R735.2[医药卫生—肿瘤] R378.99[医药卫生—临床医学]