前列腺病变组织中嗜银蛋白和增殖细胞核抗原表达及意义  

Expression of AgNOR and PCNA in benign and malignant prostatic lesions

作　　者：刘悦[1] 符庆吉[1] 王立新[1] 朱开常[1] 

机构地区：[1]解放军第210医院泌尿外科,大连116021

出　　处：《临床泌尿外科杂志》1998年第10期459-461,共3页Journal of Clinical Urology

摘　　要：为探讨早期诊断前列腺良、恶性病变的生物学行为指标，采用银染色和免疫组织化学染色法对74例前列腺良、恶性病变组织中细胞核仁组成区嗜银蛋白（AgNOR）和增殖细胞核抗原（PCNA）进行检测。结果前列腺癌组织中AgNOR和PCNA的表达明显高于前列腺非典型增生、前列腺增生症和前列腺炎（P＜0.05），其表达依次呈递减趋势。前列腺非典型增生的AgNOR和PC-NA计数介于前列腺癌与前列腺增生症之间（P＜0．05），表明前列腺非典型增生具有潜在的恶变可能。前列腺癌中AgNOR计数和PCNA增殖指数与肿瘤分化程度呈负相关（P＜0．05）。认为测定AgNOR和PCNA有助于鉴别前列腺良、恶性病变，可作为判断其生物学行为的指标。Expression of nucleolar organizer region associated protein (AgNOR) and proliferating cell nuclear antigen (PCNA) were assayed using silver-staining and immunohistochemical methods in 74 cases of benign and malignant prostatic lesions. The results showed that the expressions of AgNOR and PCNA in prostatic cancer were significantly higher than those in dysplasia,benign prostatic hyperplasis and prostatitis (P＜0. 05). The expressions of AgNOR and PCNA in prostatic cancer were inversely correlated with the degree of prostatic cancer differentiation (P <0. 05). It was suggested that the expression of AgNOR and PCNA ndght serve as a useful marker for the differentiation of benign and malignant prostatic lesions and the assessment of the biological behavior of prostatic cancer.

关 键 词：前列腺肿瘤 AGNOR 增殖细胞核抗原 

分 类 号：R737.250.2[医药卫生—肿瘤]