超声引导间质性激光动力学疗法治疗肝癌新方法  

Application of Interstitial Photodynamic Therapy for Liver Cancer under Real time US Guidance

作　　者：吕国荣[1,2] 陈骥[1,2] 王静意[1,2] 曾超英[1,2] 杨栋[1,2] 黄萍[1,2] 张惠娟[1,2] 黄木印 

机构地区：[1]福建医科大学附属二院 [2]厦门大学抗癌研究中心

出　　处：《中华超声影像学杂志》1998年第6期362-365,共4页Chinese Journal of Ultrasonography

基　　金：福建省"八五"攻关基金

摘　　要：报道３０例超声引导间质性激光动力学疗法（ｉｎｔｅｒｓｔｉｔｉａｌｐｈｏｔｏｄｙｎａｍｉｃｔｈｅｒａｐｙ，ＩＰＤＴ）治疗中晚期肝癌新方法的临床应用结果，旨在评价其临床应用价值。采用氩激光泵浦染料激光器，获得６３０ｎｍ波长的连续治疗光，光敏剂选用血卟啉衍生物（ＨｐＤ），于超声引导下将光纤导入肿瘤组织内进行间质性照射。结果表明：①有１４例患者仅行一次治疗（其中５例失访），肿瘤部分缓解率为２２％，１６例患者接受２～３次治疗，肿瘤部分缓解率达６２％。随访病例中已有８例存活一年以上。②所有病例未见严重并发症。这种治疗方法是一种有效而安全的治疗肝癌新方法。To evaluate the efficacy of interstitial photodynamic therapy (IPDT) for liver cancer, 30 patients with liver cancer were treated with IPDT under US guidance. An argon laser pumped dye laser system was used to give a CW laser beam at 630 nm. The patients were injected intravenously with photosensitizer hematoporphyrin derivative (HpD) at a dose of 5 mg/kg body weight 48 h before IPDT. Then the optical fibers were inserted into tumor under ultrasound guidance, the tumors were irradiated with CW laser. Clinical results showed that ①14 cases were treated only one time, the partial remission rate of the tumor was 22%, 16 cases were treated by 2￣3 times, the partial remission rate of tumors was 62%. In 8 cases the survival time was over one year; ②No severe complication and side reaction were found after IPDT in this series. It is suggested that IPDT is a safe and effective new method for treatment of liver cancer.

关 键 词：肝癌 光动力学疗法 血卟啉衍生物 激光 

分 类 号：R735.705[医药卫生—肿瘤]